Results 61 to 70 of about 11,196 (277)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epichloë endophytes alter inducible indirect defences in host grasses. [PDF]

PLoS ONE, 2014
Epichloë endophytes are common symbionts living asymptomatically in pooid grasses and may provide chemical defences against herbivorous insects. While the mechanisms underlying these fungal defences have been well studied, it remains unknown whether ...
Tao Li, James D Blande, Pedro E Gundel, Marjo Helander, Kari Saikkonen   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Maternal Provisioning of Offspring With Defence Chemicals in a Facultatively Parthenogenetic Stick Insect

Ecology and Evolution
Parents can invest in offspring by transferring environmental factors, such as nutrients or diet‐derived defence chemicals, into eggs or embryos. However, in systems where females can reproduce facultatively without a male (facultative parthenogenesis ...
Ana Caroline Oliveira Vasconcelos, Lewis Adler, Russell Bonduriansky   +2 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Defenses of whirligig beetles against native and invasive frogs [PDF]

PeerJ
Many native insects have evolved defenses against native predators. However, their defenses may not protect them from non-native predators due to a limited shared history.
Shinji Sugiura, Masakazu Hayashi
doaj   +2 more sources

Effects of insularity on insect leaf herbivory and chemical defences in a Mediterranean oak species [PDF]

, 2019
Aim Research on plant–herbivore interactions has shown that islands typically have low abundances and diversity of herbivores because of barriers to dispersal, isolation and reduced land area.
García-Verdugo, Carlos, Galmán, Andrea, Xoaquín Moreira, Asier R. Larrinaga, Fyllas, Nikolaos, Abdala‐Roberts, Luis, Fyllas, Nikolaos M., García‐Verdugo, Carlos, Mata Pombo, Raúl de la, Bastien Castagneyrol, Larrinaga, Asier R., Castagneyrol, Bastien, de la Mata, Raúl, Carlos García‐Verdugo, Larrinaga, Asier, Moreira, Xoaquín, Raúl de la Mata, Luis Abdala‐Roberts, Abdala-Roberts, Luis, Mata, Raúl, Nikolaos M. Fyllas, Andrea Galmán, Moreira Tomé, Xoaquín   +22 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source