Results 41 to 50 of about 384,598 (248)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
NMRium: Teaching nuclear magnetic resonance spectra interpretation in an online platform
Beilstein Journal of Organic ChemistryNMRium is the first web-based software that allows displaying, processing, interpretation, and teaching of 1D and 2D NMR data in a user-friendly interface. It can import the most common data formats (e.g., JCAMP-DX, Bruker, Varian, and Jeol).
Luc Patiny +8 more
doaj +1 more source
Química Nova, 2005 In this work we describe an experiment for the thermal cracking of octane and heptane and the qualitative analyses of the products using the Baeyer test for unsaturated compounds and gas chromatographic analyses.
Silvio Cunha +5 more
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A simple theoretical, quantitative approach to help understand the titration of weak acids and bases
Chemistry Teacher International, 2021 What happens at the very beginning of the titration of a weak acid or base is a question sometimes asked by undergraduate students when introduced to the concept of buffer solution.
Arocena Miguel
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
ESTUDOS ENVOLVENDO LINGUAGEM E EDUCAÇÃO QUÍMICA NO PERÍODO DE 2000 A 2008 - ALGUMAS CONSIDERAÇÕES
Ensaio Pesquisa em Educação em CiênciasA incorporação dos trabalhos de Lev S. Vigotsky às pesquisas em ensino de Ciências gerou articulações entre linguagem e Educação Científica no sentido de se estudar a utilização e papel das analogias nesse contexto e o discurso, leitura e escri ta no ...
Cristhiane Cunha Flor, Suzani Cassiani
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Química Nova, 2003 The toxic heavy metals can not be transformed in other less toxic substances as organic wastes through chemical process. Various chemistry courses at Faculty of Philosophy, Sciences and Humanities (FFCLRP/USP) use heavy metals in their experimental ...
Abreu Daniela Gonçalves de +1 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source