Results 81 to 90 of about 1,425,518 (291)

Cooperative WebLab in chemical engineering between France and Brazil: Validation of the methodology [PDF]

, 2012
A WebLab is an experiment operated remotely via Internet. Besides the strictly technical aspects of such an experiment, which may contribute to the learning of Chemical Engineering fundamentals, there is also important feedback when teams of students of ...
Antonio J.G. Cruz, Badino, Charles D.F. de Jesus, Claudio A.O. Nascimento, David Rouzineau, Galo Carrillo LeRoux, Henry, Klein, Marion Alliet-Gaubert, Moros, Roberto C. Giordano, Selmer, Shin, Xavier Joulia   +13 more
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

HYBRID ATOMIC ORBITALS IN ORGANIC CHEMISTRY. PART 1: CRITIQUE OF FORMAL ASPECTS

Química Nova
The importance of hybrid atomic orbitals, both historically and mathematically, is reviewed. Our new analysis of the original derivation of the sp3, sp2, sp model reveals serious errors.
Guy Lamoureux, John F. Ogilvie
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Advancing global chemical education through interactive teaching tools. [PDF]

Chem Sci, 2022
Ippoliti FM, Chari JV, Garg NK.
europepmc   +1 more source

Chemical Education

, 2013
This poster represents a collection of demonstrations that were thoughtfully developed and added to the USM Chemistry Club show. Our student group works to educate our local community on the principles of chemistry and in doing so we strive to make our demonstrations safe.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Desafios da escola atual: a educação pelo trabalho A challenge for schools: work as a general educational principle

Química Nova, 2008
This work aims at investigating and proposing strategies to improve the comprehension of Chemistry concepts by high school students. One of these strategies consists in workshops that emphasize the notion of work as a general educational principle, in ...
Roberto Ribeiro da Silva, Renata Cardoso de Sá Ribeiro Razuck, Elizabeth Tunes   +2 more
doaj   +1 more source

The levels of representation in de teaching of chemistry and the categories of Peirce´s semiotics [PDF]

, 2011
This work presents a panorama of the researches in chemical education that treat of the subject of the representation of the chemical knowledge. We focused our study in those works that contemplate the model of the three different levels of the chemical ...
Daisy de Brito Rezende, Edson José Wartha   +1 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source