Results 181 to 190 of about 11,219,681 (307)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

BatGPT-Chem: A Foundation Large Model for Chemical Engineering. [PDF]

open access: yesResearch (Wash D C)
Yang Y   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Structure-property engineering and device fabrication of conjugated polymers by chemical vapor deposition

open access: yes, 2018
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2018Cataloged from PDF version of thesis. Page 223 blank.Includes bibliographical references.This thesis focuses on the in-situ molecular engineering of chemical ...
Wang, Xiaoxue,Ph. D.Massachusetts Institute of Technology.
core  

A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases. [PDF]

open access: yesNat Commun
Zhang L   +11 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Chemical Engineering of Transcription Factors Uncovered Cell-Permeable μMax Modulators. [PDF]

open access: yesJ Am Chem Soc
Harel O   +6 more
europepmc   +1 more source

Gamification In Chemical Engineering: A Research Study

open access: yes, 2022
de Paz Carmona H, Borges Chinea ME.
europepmc   +1 more source

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