Results 51 to 60 of about 506,032 (344)

Molecular transitions as probes of the physical conditions of extragalactic environments [PDF]

, 2017
Ab initio grids of time dependent chemical models, varying in gas density, temperature, cosmic ray ionization rate, and radiation field, are used as input to RADEX calculations.
Viti, Serena
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Chemical differentiation in regions of high mass star formation II. Molecular multiline and dust continuum studies of selected objects

, 2009
The aim of this study is to investigate systematic chemical differentiation of molecules in regions of high mass star formation. We observed five prominent sites of high mass star formation in HCN, HNC, HCO+, their isotopes, C18O, C34S and some other ...
Argon, Bergin, Bergin, Bergin, Bergin, Bethell, Black, Blitz, Caselli, Caselli, Caselli, Chandler, Crowther, Cyganowski, Draine, Fich, Fontani, Frerking, Harvey, I. Zinchenko, Jessop, Jijina, Kramer, Kuiper, L. Pirogov, Lintott, Malafeev, Mangum, Mangum, Mathis, Mezger, Molek, Ossenkopf, P. Caselli, Park, Pirogov, Pirogov, Salas, Schreyer, Tafalla, Tieftrunk, Tieftrunk, Turner, Turner, Ungerechts, Ungerechts, Van der Tak, Willacy, Womack, Zhekov, Zhou, Zinchenko, Zinchenko, Zinchenko, Zinchenko, Zinchenko   +55 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Chemical Features in the Circumnuclear Disk of the Galactic Center [PDF]

, 2015
The circumnuclear disk (CND) of the Galactic Center is exposed to many energetic phenomena coming from the supermassive black hole Sgr A* and stellar activities. These energetic activities can affect the chemical composition in the CND by the interaction
Aladro, R., Harada, N., Hochgürtel, S., Jiménez-Serra, I., Martin-Pintado, J., Martín, S., Menten, K. M., Requena-Torres, M. A., Riquelme, D., Viti, S.   +9 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The gas phase cyclization of deprotonated N-aryl-2-cyano-2-diazoacetamides [PDF]

, 2005
The document attached has been archived with permission from the publisher.1-Aryl-4-cyano-5-hydroxy-1,2,3-triazoles can be obtained in solution by base-catalysed cyclization of N-aryl-2-cyano-2-diazoacetamides.
Bilusich, D., Blumenthal, T., Bowie, J., Lebedev, A., Lobodin, V., Morzherin, Y., Ovcharenko, V.   +6 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A chemical ionization mass spectrometer for continuous underway shipboard analysis of dimethylsulfide in near-surface seawater [PDF]

, 2009
A compact, low-cost atmospheric pressure, chemical ionization mass spectrometer ("mini-CIMS") has been developed for continuous underway shipboard measurements of dimethylsulfide (DMS) in seawater.
de Bruyn, W. J., Lawler, M. J., Marandino, Christa, McCormick, C. A., Saltzman, E. S.   +4 more
core   +2 more sources