Results 61 to 70 of about 506,032 (344)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Perspective on the Recent Measurements of Reduced Nitrogen Compounds in the Atmosphere

Frontiers in Environmental Science, 2022
Reduced-nitrogen compounds (RNC), such as ammonia and amines, play important roles in atmospheric aerosol nucleation, secondary organic aerosol (SOA), and cloud formation processes.
S.-H. Lee
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Efficient electronic structure calculation for molecular ionization dynamics at high x-ray intensity

, 2015
We present the implementation of an electronic-structure approach dedicated to ionization dynamics of molecules interacting with x-ray free-electron laser (XFEL) pulses.
Hanasaki, Kota, Hao, Yajiang, Inhester, Ludger, Santra, Robin, Son, Sang-Kil   +4 more
core   +2 more sources

O^−• chemical ionization of carbonyl compounds [PDF]

Journal of the American Society for Mass Spectrometry, 1991
The negative ion chemical ionization mass spectra of twentyeight C4 to C7 carbonyl compounds were recorded using the oxide radical anion O(-•) as reagent ion. As noted earlier, the reactions occurring include H(+) abstraction, H 2 (+•) abstraction, H- atom displacement, and alkyl radical displacement. In addition, the [M-2H](-) ions fragment further by
Marshall, Anthony, Tkaczyk, Martin, Harrison, Alex G.   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The ionization fraction gradient across the Horsehead edge: An archetype for molecular clouds

, 2009
The ionization fraction plays a key role in the chemistry and dynamics of molecular clouds. We study the H13CO+, DCO+ and HOC+ line emission towards the Horsehead, from the shielded core to the UV irradiated cloud edge, i.e., the Photodissociation Region
Bourlot, J. Le, Gerin, M., Goicoechea, J. R., Hily-Blant, P., Pety, J.   +4 more
core   +5 more sources

The Light Curve of Supernova 1987A: The Structure of the Presupernova and Radioactive Nickel Mixing [PDF]

, 2003
We have studied the influence of the presupernova structure and the degree of Ni-56 mixing on the bolometric light curve of SN 1987A in terms of radiation hydrodynamics in the one-group approximation by abandoning LTE and by taking into account ...
Utrobin, V. P.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Density Functional Calculations On First-Row Transition Metals

, 1994
The excitation energies and ionization potentials of the atoms in the first transition series are notoriously difficult to compute accurately. Errors in calculated excitation energies can range from 1--4 eV at the Hartree-Fock level, and errors as high ...
Hay, P. Jeffrey, Martin, Richard L., Russo, Thomas V.   +2 more
core   +1 more source