Results 101 to 110 of about 4,673,395 (335)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Techno-economic analysis of chemical looping combustion with humid air turbine power cycle [PDF]

open access: yes, 2014
Power generation from fossil fuel-fired power plant is the largest single source of CO₂ emission. CO₂ emission contributes to climate change. On the other hand, renewable energy is hindered by complex constraints in dealing with large scale application ...
Brandvoll   +6 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Stochastic dynamics of macromolecular-assembly networks [PDF]

open access: yes, 2006
The formation and regulation of macromolecular complexes provides the backbone of most cellular processes, including gene regulation and signal transduction.
Arkin A   +4 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Probing the elastic limit of DNA bending

open access: yes, 2014
Many structures inside the cell such as nucleosomes and protein-mediated DNA loops contain sharply bent double-stranded (ds) DNA. Therefore, the energetics of strong dsDNA bending constitutes an essential part of cellular thermodynamics.
Kim, Harold D., Le, Tung T.
core   +1 more source

Moving Domain Computational Fluid Dynamics to Interface with an Embryonic Model of Cardiac Morphogenesis [PDF]

open access: yes, 2013
Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal.
Beebe, Tyler   +11 more
core   +7 more sources

Innovative Oxygen Carriers Uplifting Chemical-looping Combustion

open access: yesEnergy Procedia, 2014
11 figures, 6 tables.-- Work presented at the 12th International Conference on Greenhouse Gas Control Technologies, GHGT-12, 5th-9th October 2014, Austin, Texas (USA) This paper reports on the main results of the EU-financed project INNOCUOUS (Innovative Oxygen Carriers Uplifting Chemical-Looping Combustion).
Mattisson, Tobias   +7 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

1-dimensional modelling and simulation of the calcium looping process [PDF]

open access: yes, 2012
Calcium looping is an emerging technology for post-combustion carbon dioxide capture and storage in development. In this study, a 1-dimensional dynamical model for the calcium looping process was developed. The model was tested against a laboratory scale
Arias, Borja   +4 more
core   +1 more source

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