Results 121 to 130 of about 4,673,395 (335)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reactivity improvement of ilmenite by calcium nitrate melt infiltration for Chemical Looping Combustion of biomass

Carbon Resources Conversion, 2019
Chemical Looping Combustion is a novel process that generates sequestration-ready CO2 from the combustion of woody biomass without requiring a gas separation step and without diluting the CO2 with N2 from air.
Martin Keller, Hikaru Oka, Junichiro Otomo   +2 more
doaj   +1 more source

c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]

, 2007
Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Anthony P. H. Wright, Chiou-Nan Shiue, Rachel G. Berkson   +2 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Chemical looping beyond combustion: production of synthesis gas via chemical looping partial oxidation of methane

RSC Adv., 2014
Systematic development of Fe–Ni bimetallic carrier results in efficient and safe chemical looping process for methane partial oxidation to syngas.
Saurabh Bhavsar, Götz Veser
openaire   +1 more source

Ash chemistry in chemical looping process for biomass valorization: A review

Chemical Engineering Journal, 2023
Yurui Liu, Ke Yin, Jiawei Wu, D. Mei, J. Konttinen, T. Joronen, Zhifeng Hu, Chao He   +7 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Comparative assessment of chemical looping assisted biomass gasification for H2 production: A Thermochemical, Exergy, and Environmental Perspective

Case Studies in Chemical and Environmental Engineering
This study conducts a comparative simulation of chemical looping-assisted biomass gasification for hydrogen-rich syngas production using Aspen Plus and HYSYS.
Rakib bin Nasir, Tae Jin Kang, Souman Rudra   +2 more
doaj   +1 more source

Integration of chemical looping oxygen production and chemical looping combustion in integrated gasification combined cycles

Fuel, 2018
Abstract Energy penalty is the primary economic challenge facing CO2 capture technology. This work aims to address this challenge through a novel power plant configuration, capable of achieving 45.4% electric efficiency from coal with a 95% CO2 capture efficiency.
Schalk Cloete, Antonio Giuffrida, Matteo Romano, Paolo Chiesa, Mehdi Pishahang, Yngve Larring   +5 more
openaire   +2 more sources