Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach [PDF]
Toxics, 2023 This study addresses the challenge of assessing the carcinogenic potential of hazardous chemical mixtures, such as per- and polyfluorinated substances (PFASs), which are known to contribute significantly to cancer development.
Sarita Limbu, Sivanesan Dakshanamurthy
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Adverse Outcome Pathway ‘Footprinting’: A Novel Approach to the Integration of 21st Century Toxicology Information into Chemical Mixtures Risk Assessment [PDF]
Toxics, 2022 For over a decade, New Approach Methodologies (NAMs) such as structure-activity/read-across, -omics technologies, and Adverse Outcome Pathway (AOP), have been considered within regulatory communities as alternative sources of chemical and biological ...
Jason C. Lambert
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The gut-brain axis mediates precocious puberty induced by environmentally relevant low-dose endocrine-disrupting chemical mixtures [PDF]
Frontiers in EndocrinologyBackgroundThe global rise in precocious puberty (PP) is increasingly linked to exposure to endocrine-disrupting chemicals (EDCs). However, the mechanisms by which environmentally relevant, low-dose mixtures of EDCs influence PP remain inadequately ...
Hui Wu +5 more
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Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents [PDF]
Toxics, 2021 Inhibition, one of the building blocks of executive function, is the ability to focus one’s attention despite interference from external stimuli. It undergoes substantial development during adolescence and may be susceptible to adverse impacts of ...
Anna V. Oppenheimer +5 more
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A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures [PDF]
Toxics, 2022 Human cell-based population-wide in vitro models have been proposed as a strategy to derive chemical-specific estimates of inter-individual variability; however, the utility of this approach has not yet been tested for cumulative exposures in mixtures ...
Lucie C. Ford +7 more
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Genotoxicity assessment of chemical mixtures
EFSA Journal, 2019 The EFSA Scientific Committee addressed in this document the peculiarities related to the genotoxicity assessment of chemical mixtures. The EFSA Scientific Committee suggests that first a mixture should be chemically characterised as far as possible ...
EFSA Scientific Committee +27 more
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Environment International, 2020 The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present.
Elina Drakvik +25 more
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The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease [PDF]
Open Research EuropeThe true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals ...
Ana Claudia Zenclussen +40 more
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Comparative analysis of the performance of mixing rules for density prediction of simple chemical mixtures [PDF]
Журнал інженерних наук, 2021 Four different mixing rules (MRs) in three equations of state (EOSs) have been used to account for the intermolecular forces of attraction between dissimilar molecules of different substances that form simple mixtures.
Babalola F. U., Akanji I. O., Oyegoke T.
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Prenatal Exposure to Chemical Mixtures and Cognitive Flexibility among Adolescents
Toxics, 2021 Cognitive flexibility, the ability to smoothly adapt to changing circumstances, is a skill that is vital to higher-level executive functions such as problem-solving, planning, and reasoning.
Anna V. Oppenheimer +4 more
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