Results 71 to 80 of about 6,480,350 (293)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Chemical modification of biocatalysts
Current Opinion in Biotechnology, 2003 Although several powerful methods exist for the redesign of enzyme structure and function these are typically limited to the 20 most abundant proteinogenic amino acids. The use of chemical modification overcomes this limitation to allow virtually unlimited alteration of amino acid sidechain structures.
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Recent Progress in Chemical Modification of Proteins
Analytical Sciences, 2019 Chemical modification of proteins is important for creating a myriad of engineered proteins and for elucidating the function and dynamics of proteins in live cells.
S. Sakamoto, I. Hamachi
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Intermolecular selective carboacylation of alkenes via nickel-catalyzed reductive radical relay
Nature Communications, 2018 To date the carboacylation of alkenes has been reported only in single- and two-component methodologies. Here, the authors report a three-component nickel-catalyzed carboacylation of olefins which enables the rapid construction of ketones with high ...
Xian Zhao +5 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Nano-Micro LettersHighlights A lamellar-structured fluorinated cellulose nanofiber aerogel film is prepared by filtration-induced delaminated gelation and ambient drying.
Meng Lian +7 more
doaj +1 more source
Preparation and Application of Modified Vermiculite Adsorption Materials
Kuangchan zonghe liyongβ-Cd polymer (KACD) was prepared by modifying β-Cd with KH560 at alkaline conditions, and then the polymer was loaded onto vermiculite to prepare β-Cd modified vermiculite composite (KACDS).
Huicong DU +7 more
doaj +1 more source
Nature Communications, 2018 Converting alkynes into alkenes with high stereoselectivity via two consecutive C-C bond forming steps is a desirable process, yet very challenging. Here, the authors describe a dual photoredox-nickel catalytic system for the regio- and syn-selective ...
Lei Guo +4 more
doaj +1 more source