Results 51 to 60 of about 652,135 (265)

AlN-based aerogel thermo-cooler enabled by enhanced phonon conduction and unconstrained liquid capillarity

Nature Communications
Transpiration cooling is a thermal management technique that utilizes the phase change of liquid coolant to effectively dissipate heat. Porous ceramic media play a crucial role in this cooling process by facilitating liquid transport and heat exchange ...
Shengnan Meng, Hongxing Wang, Qian Zhao, Xiaozhou Lü, Jianyong Yu, Yang Si   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Enzymatic Degradation Behavior and Molecular Weight Regulation of Dextran: Empirical Modeling and Multi-Scale Structural Characterization

Current Issues in Molecular Biology
To meet the demand for controlled production of low-molecular-weight (Mw < 10 kDa) dextran with potential pharmaceutical applications, this study developed an efficient enzymatic preparation process using PC-Edex, a dextranase derived from Penicillium ...
Mei Li, Piaoran Fan, Yirui Zhang, Ranran Li, Lemin Chen, Donghui Zhang, Lei Zhong   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica

Advanced Science
The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier‐based delivery strategies focus on conventional PSs, neglecting the critical ...
Yan Liu, Xiang Wang, Ben Wang, Zhenni Lu, Changru Wu, Zhanghao He, Libo Jiang, Peng Wei, Tao Yi   +8 more
doaj   +1 more source

Intermolecular selective carboacylation of alkenes via nickel-catalyzed reductive radical relay

Nature Communications, 2018
To date the carboacylation of alkenes has been reported only in single- and two-component methodologies. Here, the authors report a three-component nickel-catalyzed carboacylation of olefins which enables the rapid construction of ketones with high ...
Xian Zhao, Hai-Yong Tu, Lei Guo, Shengqing Zhu, Feng-Ling Qing, Lingling Chu   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source