Results 41 to 50 of about 650,908 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Aerogel-based Leidenfrost vapor percolator for ultra-fast thermal cooling

Nature Communications
The Leidenfrost effect—where liquid droplets levitate on superheated surfaces—hinders efficient heat transfer. Conventional mitigation strategies typically rely on rigid materials with complex surface engineering, but their applicability is limited by ...
Hongxing Wang, Yiheng Xu, Panpan Li, Qingjun Liu, Longdi Cheng, Jianyong Yu, Yang Si   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mechanically Strong, Freeze‐Resistant, and Ionically Conductive Organohydrogels for Flexible Strain Sensors and Batteries

Advanced Science, 2023
Conductive hydrogels as promising material candidates for soft electronics have been rapidly developed in recent years. However, the low ionic conductivity, limited mechanical properties, and insufficient freeze‐resistance greatly limit their ...
Jiayu Lyu, Qingya Zhou, Haifeng Wang, Qi Xiao, Zhe Qiang, Xiaopeng Li, Jin Wen, Changhuai Ye, Meifang Zhu   +8 more
doaj   +1 more source

Mapping of the Chemical Modifications of rRNAs

, 2022
AbstractCellular RNAs, both coding and noncoding, contain several chemical modifications. Both ribose sugars and nitrogenous bases are targeted for these chemical additions. These modifications are believed to expand the topological potential of RNA molecules by bringing chemical diversity to otherwise limited repertoire.
Jun, Yang, Peter, Watzinger, Sunny, Sharma   +2 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Self-adaptable mechanical ceramic fibrous aerogels from prestressed topology and multistable constraints

Nature Communications
Ceramic aerogels, widely used as thermal insulation materials, are renowned for their remarkable characteristics, including ultralight weight and ultralow thermal conductivity. However, their application is often limited by susceptibility to damage under
Hongxing Wang, Longdi Cheng, Jianyong Yu, Yang Si   +3 more
doaj   +1 more source

Green Synthesis of Pyridyl Conjugated Microporous Polymers as Precursors for Porous Carbon Microspheres for Efficient Electrochemical Energy Storage

ChemElectroChem, 2020
Efficient materials for electrochemical energy storage have received much attention. Herein we report a green metal‐free route to synthesize pyridyl conjugated microporous polymers (PCMPs) as precursors for nitrogen‐doped porous carbon microspheres (NCMs)
Yan He, Zhonghua Cheng, Hongyu Zuo, Chunna Yan, Prof. Dr. Yaozu Liao   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source