Results 51 to 60 of about 1,090,573 (294)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

EXPERIMENTAL STUDY OF REACTIVITY AND MORPHOLOGICAL CHANGE OF FE-BASED CHEMICAL LOOPING PARTICLE IN CYCLIC REDUCTION-OXIDATION REACTIONS [PDF]

, 2013
Coal, an abundant and stable energy source, is playing an important role in current and future global energy supplies. Therefore, there is intensive research currently focusing on coal-conversion in a high-efficiency and environmentally-friendly way. The
Chi, Hao
core  

Analytical Solution for facilitated transport across a membrane [PDF]

, 2002
An analytical expression for the facilitation factor of component A across a liquid membrane is derived in case of an instantaneous reaction A(g)+B(l)AB(l) inside the liquid membrane.
Al-Marzouqi, Mohamed Hassan, Hogendoorn, Kees J.A., Versteeg, Geert F.   +2 more
core   +5 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Interfacial thermal conductance in graphene/black phosphorus heterogeneous structures

, 2016
Graphene, as a passivation layer, can be used to protect the black phosphorus from the chemical reaction with surrounding oxygen and water. However, black phosphorus and graphene heterostructures have low efficiency of heat dissipation due to its ...
Cai, Kun, Chen, Yang, Jiang, Jinwu, Wei, Ning, Zhang, Yingyan, Zhao, Junhua, Zheng, Jin-cheng   +6 more
core   +1 more source

Lime stabilisation for earthworks: a UK perspective [PDF]

, 2014
Lime stabilisation is a versatile technique applied during earthworks operations. Modern soil recycling units are much more efficient at pulverising fill material and intermixing the added binder/water than machinery available 20 years ago.
Beetham P, Bell FG, Bergado DT, Bin S, Bohn HL, BSI, BSI, BSI, Davidson LK, Diamond S, Eades JE, Greaves HM, Highways Agency, Highways Agency, Highways Agency, Holt CC, Ingles OG, John Bateman, Longworth I, McAllister LD, Mitchell JK, Neil Dixon, Paul Beetham, Paul Fleming, Perry J, Petry TM, Reeves GM, Robert Hutchison, Rowell DL, Sherwood PT, Sherwood PT, Snedker EA, Stocker PT, Sweeney DA, Taylor HFW, Tom Dijkstra, Van Olphen H, Winter NB   +37 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Inter-molecular Adaptive Collision Scheme for Chemical Reaction Optimization

, 2015
Optimization techniques are frequently applied in science and engineering research and development. Evolutionary algorithms, as a kind of general-purpose metaheuristic, have been shown to be very effective in solving a wide range of optimization problems.
Lam, Albert Y. S., Li, Victor O. K., Yu, James J. Q.   +2 more
core   +1 more source

UNSTEADY MIXED CONVECTION WITH SORET AND DUFOUR EFFECTS PAST A POROUS PLATE MOVING THROUGH A BINARY MIXTURE OF CHEMICALLY REACTING FLUID [PDF]

, 2011
This study investigates the unsteady mixed convection flow past a vertical porous flat plate moving through a binary mixture in the presence of radiative heat transfer and nth-order Arrhenius type of irreversible chemical reaction by taking into ...
makinde, D.O., Olanrewaju, P. O.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source