Results 71 to 80 of about 377,256 (259)

Room‐Temperature Direct Homolysis of Csp3─H Bond via Catalyst‐Free Photoexcitation

Exploration
The C─H bond is the most abundant chemical bond in organic compounds. Therefore, the development of the more direct methods for C─H bond cleavage and the elucidation of their mechanisms will provide an important theoretical basis for achieving more ...
Qi Miao, Meng Liu, Jun Wang, Pan Wu, Changjun Liu, Jian He, Giacomo Lo Zupone, Wei Jiang   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Crystal structure of octa-aqua-terbium(III) sesqui-anthraquinone-2,6- disulfonato sesqui-4,4'-bipyridyl tetrahydrate (1:1.5:1.5:4), [Tb(H2O)8]·(C14H6S2O8)1.5·(C10H8N2)1.5·(H2O)4, C36H45N3O24S3Tb

Zeitschrift für Kristallographie - New Crystal Structures, 2013
C36H45N3O24S3Tb, triclinic, P1¯ (no. 2), a = 10.0869(7) Å, b = 13.7894(8) Å, c = 17.6966(8) Å, α = 69.366(4)°, β = 74.359(5)°, γ = 85.267(6)°, V = 2218.0 Å3, Z = 2, Rgt(F) = 0.0369, wRref(F2) = 0.0817, T = 273 K.
Hou Xiang-Yang, Fu Feng, Wang Ji-Jiang, Tang Long, Cao Jia, Lei Lv   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Single/dual-metal active-site oxides for rechargeable zinc-air batteries: Fundamental properties, advancements, challenges, and future perspectives

Carbon Future
Rechargeable zinc-air batteries (RZABs) are considered one of the most promising candidates for advanced energy storage and conversion in the near future.
Yunrui Li, Ping Zhu, Fan Lan, Run Li, Ya Huang, Rufan Zhang   +5 more
doaj   +1 more source

Rate-selected growth of ultrapure semiconducting carbon nanotube arrays

Nature Communications, 2019
Carbon nanotubes are considered promising materials for microelectronics, but it is challenging to separate semiconducting tubes from their metallic counterparts. Here, the authors report a self-purification growth process that allows them to obtain long,
Zhenxing Zhu, Nan Wei, Weijun Cheng, Boyuan Shen, Silei Sun, Jun Gao, Qian Wen, Rufan Zhang, Jun Xu, Yao Wang, Fei Wei   +10 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Ultrasmall single-layered NbSe2 nanotubes flattened within a chemical-driven self-pressurized carbon nanotube

Nature Communications
Pressure can alter interatomic distances and its electrostatic interactions, exerting a profound modifying effect on electron orbitals and bonding patterns.
Yaxin Jiang, Hao Xiong, Tianping Ying, Guo Tian, Xiao Chen, Fei Wei   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Molecular design of amphiphilic triblock copolymers as additives for high performance poly(vinyl chloride) ultrafiltration membranes

Scientific Reports
Amphiphilic triblock copolymers (TBCs) of poly(styrene)-b-polyethylene glycol-b-poly(styrene) (PS-b-PEG-b-PS) were synthesized by atom transfer radical polymerization (ATRP) and added to poly(vinyl chloride) (PVC) to prepare ultrafiltration (UF) blend ...
Hasan Alshammari, Maral Ghahramani, Alireza Sharif   +2 more
doaj   +1 more source