Results 71 to 80 of about 356,743 (287)

Shape differentiation of a steady-state reaction-diffusion problem\n arising in Chemical Engineering: the case of non-smooth kinetic with dead\n core [PDF]

, 2017
David Gómez‐Castro
openalex   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Crystal structure of octa-aqua-terbium(III) sesqui-anthraquinone-2,6- disulfonato sesqui-4,4'-bipyridyl tetrahydrate (1:1.5:1.5:4), [Tb(H2O)8]·(C14H6S2O8)1.5·(C10H8N2)1.5·(H2O)4, C36H45N3O24S3Tb

Zeitschrift für Kristallographie - New Crystal Structures, 2013
C36H45N3O24S3Tb, triclinic, P1¯ (no. 2), a = 10.0869(7) Å, b = 13.7894(8) Å, c = 17.6966(8) Å, α = 69.366(4)°, β = 74.359(5)°, γ = 85.267(6)°, V = 2218.0 Å3, Z = 2, Rgt(F) = 0.0369, wRref(F2) = 0.0817, T = 273 K.
Hou Xiang-Yang, Fu Feng, Wang Ji-Jiang, Tang Long, Cao Jia, Lei Lv   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Ultrasmall single-layered NbSe2 nanotubes flattened within a chemical-driven self-pressurized carbon nanotube

Nature Communications
Pressure can alter interatomic distances and its electrostatic interactions, exerting a profound modifying effect on electron orbitals and bonding patterns.
Yaxin Jiang, Hao Xiong, Tianping Ying, Guo Tian, Xiao Chen, Fei Wei   +5 more
doaj   +1 more source

Single/dual-metal active-site oxides for rechargeable zinc-air batteries: Fundamental properties, advancements, challenges, and future perspectives

Carbon Future
Rechargeable zinc-air batteries (RZABs) are considered one of the most promising candidates for advanced energy storage and conversion in the near future.
Yunrui Li, Ping Zhu, Fan Lan, Run Li, Ya Huang, Rufan Zhang   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Rate-selected growth of ultrapure semiconducting carbon nanotube arrays

Nature Communications, 2019
Carbon nanotubes are considered promising materials for microelectronics, but it is challenging to separate semiconducting tubes from their metallic counterparts. Here, the authors report a self-purification growth process that allows them to obtain long,
Zhenxing Zhu, Nan Wei, Weijun Cheng, Boyuan Shen, Silei Sun, Jun Gao, Qian Wen, Rufan Zhang, Jun Xu, Yao Wang, Fei Wei   +10 more
doaj   +1 more source