Results 131 to 140 of about 470,770 (313)

Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling

Communications Chemistry
The thiol-ene reaction between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications. Here, we explore thiol-ene activation in systems from chemical models to complex cellular milieus, using
André Campaniҫo, Marcin Baran, Andrew G. Bowie, Daniel B. Longley, Timothy Harrison, Joanna F. McGouran   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Impact of Thermodynamic Constraints on the Lability of Activation Energy as a Function of Conversion Degree

Energies
The subject concerns the determination of activation energy under dynamic conditions using two theoretical isothermal models, and subsequently experimental data, with reference to the α–T relationship matrix.
Andrzej Mianowski, Rafał Bigda, Tomasz Radko   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

BatGPT-Chem: A Foundation Large Model for Chemical Engineering

Research
Large language models (LLMs) have showcased remarkable capabilities in the realm of AI for Science, and chemistry has greatly benefited from the advancement of AI tools.
Yifei Yang, Runhan Shi, Zuchao Li, Shu Jiang, Bao-Liang Lu, Qibin Zhao, Yang Yang, Hai Zhao   +7 more
doaj   +1 more source

Identification of Dynamical Models of Spatio-temporal Pattern Formation with Applications to Slime Mould [PDF]

, 2011
Spatio-temporal systems are non-linear dynamical systems which include both time and space information. Many natural phenomena and processes can be described by spatio-temporal models, such as pattern formation, chemical reactions and physical dynamics ...
Wang, Shu
core  

Hydrogen generation from alcohols catalyzed by ruthenium-triphenylphosphine complexes : multiple reaction pathways

, 2010
We report a comprehensive density functional theory (DFT) study of the mechanism of the methanol dehydrogenation reaction catalyzed by [RuH2(H2)(PPh3)3].
Bühl, Michael, Sieffert, Nicolas, Buehl, Michael   +2 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Student Translations of the Symbolic Level of Chemistry

Education Sciences
The aim of the study was to explore students’ own translation of the symbolic level of a chemical reaction, including the information provided with the use of coefficients, indices, and signs, as well as the preservation of atoms.
Gunilla Akesson-Nilsson, Karina Adbo
doaj   +1 more source