Results 111 to 120 of about 1,196,417 (299)

Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling

Communications Chemistry
The thiol-ene reaction between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications. Here, we explore thiol-ene activation in systems from chemical models to complex cellular milieus, using
André Campaniҫo, Marcin Baran, Andrew G. Bowie, Daniel B. Longley, Timothy Harrison, Joanna F. McGouran   +5 more
doaj   +1 more source

The study of PDF turbulence models in combustion [PDF]

In combustion computations, it is known that the predictions of chemical reaction rates are poor if conventional turbulence models are used. The probability density function (pdf) method seems to be the only alternative that uses local instantaneous ...
Hsu, Andrew T.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation of Models for Online Runaway Detection at the Esterification of Acetic Anhydride with Methanol

Chemical Engineering Transactions
Models for the online detection of runaway reactions in chemical plants promise to increase the safe operation of chemical processes. However, a general industrial application has not been achieved for these models.
Carsten Schmidt, Jürgen Schmidt, Jens Denecke, Yongbo Xin   +3 more
doaj  

Roles of network topology in the relaxation dynamics of simple chemical reaction network models

Scientific Reports
Understanding the relationship between the structure of chemical reaction networks and their reaction dynamics is essential for unveiling the design principles of living organisms.
Yusuke Himeoka, Julius B. Kirkegaard, Namiko Mitarai, Sandeep Krishna   +3 more
doaj   +1 more source

New trends in combustion research for gas turbine engines [PDF]

Research on combustion is being conducted to provide improved analytical models of the complex flow and chemical reaction processes which occur in the combustor of gas turbine engines, in order to enable engine manufacturers to reduce the development ...
Mularz, E. J.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Impact of Thermodynamic Constraints on the Lability of Activation Energy as a Function of Conversion Degree

Energies
The subject concerns the determination of activation energy under dynamic conditions using two theoretical isothermal models, and subsequently experimental data, with reference to the α–T relationship matrix.
Andrzej Mianowski, Rafał Bigda, Tomasz Radko   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

BatGPT-Chem: A Foundation Large Model for Chemical Engineering

Research
Large language models (LLMs) have showcased remarkable capabilities in the realm of AI for Science, and chemistry has greatly benefited from the advancement of AI tools.
Yifei Yang, Runhan Shi, Zuchao Li, Shu Jiang, Bao-Liang Lu, Qibin Zhao, Yang Yang, Hai Zhao   +7 more
doaj   +1 more source