Results 91 to 100 of about 13,754,171 (302)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Maximum probability reaction sequences in stochastic chemical kinetic systems
Frontiers in Physiology, 2010 The detailed behavior of many molecular processes in the cell, such as protein folding, protein complex assembly, and gene regulation, transcription and translation, can often be accurately captured by stochastic chemical kinetic models. We investigate a
Maryam Salehi +2 more
doaj +1 more source
Journal of CheminformaticsFinding optimal reaction conditions is crucial for chemical synthesis in the pharmaceutical and chemical industries. However, due to the vast chemical space, conducting experiments for all the possible combinations is impractical.
Shih-Cheng Li +9 more
doaj +1 more source
Accurate Theoretical Study of Chemical Reaction Dynamics
, 2008 I will present some of our recent work on theoretical studies of chemical reaction dynamics at a quantitative level which combines accurately constructed potential energy surfaces and quantum reactive scattering calculations. I will first introduce a new
张东辉, Dong Hui Zhang
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Atmosphere, 2019 Studies in actual urban settings that integrate chemical reaction modeling, radiation, and particular emissions are mandatory to evaluate the effects of traffic-related air pollution on street canyons.
Franchesca G. Gonzalez Olivardia +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Students' Mental Models of Chemical Reactions [PDF]
, 2013 Previous research on topics such as atomic structure and chemical bonding indicates that students’ mental models are often inconsistent with the scientific models, which may impede learning of advanced concepts.
Lajium, Denis Andrew D
core
, 2022 Heuristic and machine learning models for rank-ordering reaction templates comprise an important basis for computer-aided organic synthesis regarding both product prediction and retrosynthetic pathway planning.
Green Jr, William H +3 more
core +1 more source