Results 91 to 100 of about 470,770 (313)

Analysis of Pollutant Dispersion in a Realistic Urban Street Canyon Using Coupled CFD and Chemical Reaction Modeling

Atmosphere, 2019
Studies in actual urban settings that integrate chemical reaction modeling, radiation, and particular emissions are mandatory to evaluate the effects of traffic-related air pollution on street canyons.
Franchesca G. Gonzalez Olivardia, Qi Zhang, Tomohito Matsuo, Hikari Shimadera, Akira Kondo   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Application of the digital annealer unit in optimizing chemical reaction conditions for enhanced production yields

Journal of Cheminformatics
Finding optimal reaction conditions is crucial for chemical synthesis in the pharmaceutical and chemical industries. However, due to the vast chemical space, conducting experiments for all the possible combinations is impractical.
Shih-Cheng Li, Pei-Hua Wang, Jheng-Wei Su, Wei-Yin Chiang, Tzu-Lan Yeh, Alex Zhavoronkov, Shih-Hsien Huang, Yen-Chu Lin, Chia-Ho Ou, Chih-Yu Chen   +9 more
doaj   +1 more source

Maximum probability reaction sequences in stochastic chemical kinetic systems

Frontiers in Physiology, 2010
The detailed behavior of many molecular processes in the cell, such as protein folding, protein complex assembly, and gene regulation, transcription and translation, can often be accurately captured by stochastic chemical kinetic models. We investigate a
Maryam Salehi, Theodore ePerkins, Theodore ePerkins   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Image based validation of dynamical models for cell reorientation [PDF]

, 2015
A key feature of directed cell movement is the ability of cells to reorient quickly in response to changes in the direction of an extracellular stimulus.
Ladds, Graham, Lockley, Robert, Graham Ladds, Bretschneider, Till, Robert Lockley, Till Bretschneider   +5 more
core   +1 more source

Growing strings in a chemical reaction space for searching retrosynthesis pathways

, 2023
Machine learning algorithms have shown great accuracy in predicting chemical reaction outcomes and retrosynthesis. However, designing synthesis pathways remains challenging for existing machine learning models which are trained for single-step prediction.
Carlo, Baldassari, Matteo, Manica, Jannis, Born, Teodoro, Laino, Federico, Zipoli   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pattern formation in reaction diffusion models with spatially inhomogeneous diffusion coefficients

, 1992
Reaction-diffusion models for biological pattern formation have been studied extensively in a variety of embryonic and ecological contexts. However, despite experimental evidence pointing to the existence of spatial inhomogeneities in various biological ...
Sherratt, J. A., BENSON, D, MAINI, P, Maini, P. K., Benson, D. L., SHERRATT, J, Sherratt, Jonathan Adam, Benson, D.L., Maini, P.K., MAINI, Philip   +9 more
core   +1 more source

Stratospheric ozone in 3-D models: A simple chemistry and the cross-tropopause flux [PDF]

, 2000
Two simple and computationally efficient models for simulating stratospheric ozone in three-dimensional global transport models are presented. The first, linearized ozone (or Linoz), is a first-order Taylor expansion of stratospheric chemical rates in ...
McLinden, C. A, Olsen, SC, B. Hannegan, Wild, O., Sundet, J., Prather, MJ, McLinden, CA, J. Sundet, S. C. Olsen, Hannegan, B, Wild, O, C. A. McLinden, O. Wild, M. J. Prather, Hannegan, B., Prather, M. J, Olsen, S. C, Sundet, J   +17 more
core   +1 more source