Results 71 to 80 of about 470,770 (313)

Prediction of Chemical Reactions Using Statistical Models of Chemical Knowledge

, 2018
Is chemistry discoverable or can it only be invented? – this is the question of a computer scientist and a philosopher of science when looking at application of artificial intelligence methods for developing new chemical entities and new chemical ...
Philipp-Maximilian, Jacob, Alexei, Lapkin   +1 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

PREDICTION OF REACTION CONDITIONS BY DEEP LEARNING TECHNIQUES [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2020
Subject of Research. The paper presents a study of prediction method for various properties of reactions, such as the type of reaction, suitable groups of solvents, catalysts for the reaction.
Vladimir B. Moskalev, Evgeniy O. Putin
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

ANALISIS PROFIL MODEL MENTAL SISWA SMA PADA MATERI LAJU REAKSI

Jurnal Penelitian dan Pembelajaran IPA, 2015
The research, entitled "Analysis Students’ Profile Mental Models High School on the rate of reaction" aims to obtain an overview of high school students' mental modelson the rate of reaction.
Yuli Handayanti, Agus Setiabudi, Nahadi
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Suitability of large language models for extraction of high-quality chemical reaction dataset from patent literature

Journal of Cheminformatics
With the advent of artificial intelligence (AI), it is now possible to design diverse and novel molecules from previously unexplored chemical space. However, a challenge for chemists is the synthesis of such molecules.
Sarveswara Rao Vangala, Sowmya Ramaswamy Krishnan, Navneet Bung, Dhandapani Nandagopal, Gomathi Ramasamy, Satyam Kumar, Sridharan Sankaran, Rajgopal Srinivasan, Arijit Roy   +8 more
doaj   +1 more source

Influence of chemical denudation on hillslope morphology [PDF]

, 2004
[1] Models of hillslope evolution involving diffusion-like sediment transport are conventionally presented as an equation in which the changes in land-surface elevation or soil thickness are balanced by the divergence of soil transport and tectonic ...
Furbish, D. J., Mudd, Simon; id_orcid, Simon Marius Mudd, David Jon Furbish   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Prediction of chemical reaction yields with large-scale multi-view pre-training

Journal of Cheminformatics
Developing machine learning models with high generalization capability for predicting chemical reaction yields is of significant interest and importance.
Runhan Shi, Gufeng Yu, Xiaohong Huo, Yang Yang   +3 more
doaj   +1 more source