Results 91 to 100 of about 617,908 (340)
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Gene Expression and its Discontents: Developmental disorders as dysfunctions of epigenetic cognition [PDF]
, 2009 Systems biology presently suffers the same mereological and sufficiency fallacies that haunt neural network models of high order cognition. Shifting perspective from the massively parallel space of gene matrix interactions to the grammar/syntax of the ...
Wallace, Rodrick
core +2 more sources
Disentangling CO Chemistry in a Protoplanetary Disk Using Explanatory Machine-learning Techniques
The Astrophysical JournalMolecular abundances in protoplanetary disks are highly sensitive to the local physical conditions, including gas temperature, gas density, radiation field, and dust properties.
Amina Diop +4 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Reduction of dynamical biochemical reaction networks in computational biology [PDF]
, 2012 Biochemical networks are used in computational biology, to model the static and dynamical details of systems involved in cell signaling, metabolism, and regulation of gene expression.
Gorban, Alexander N. +3 more
core +6 more sources
Engineering ProceedingsModels of chemical kinetic processes, comprising systems of stiff ordinary differential equations (ODEs), are essential for modeling important chemical reactions relevant to drinking water chemistry, such as disinfectant decay and disinfection byproduct ...
Matthew Frankel +3 more
doaj +1 more source
Construction and analysis of the model of energy metabolism in E. coli. [PDF]
PLoS ONE, 2013 Genome-scale models of metabolism have only been analyzed with the constraint-based modelling philosophy and there have been several genome-scale gene-protein-reaction models. But research on the modelling for energy metabolism of organisms just began in
Zixiang Xu, Xiao Sun, Jibin Sun
doaj +1 more source
Reactions, 2022 The hydrogenation of CO and CO2 from industrial exhaust gases into CH4 represents a promising method for sustainable chemical energy storage. While iron-based catalysts are in principle suitable for that purpose, the active metal Fe undergoes a complex ...
Christian Zambrzycki, Robert Güttel
doaj +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Sensitivity analysis for stochastic chemical reaction networks with multiple time-scales [PDF]
, 2013 Stochastic models for chemical reaction networks have become very popular in recent years. For such models, the estimation of parameter sensitivities is an important and challenging problem. Sensitivity values help in analyzing the network, understanding
Ankit Gupta, M. Khammash
semanticscholar +1 more source