Results 151 to 160 of about 617,908 (340)
Enzyme economy in metabolic networks
, 2014 Metabolic systems are governed by a compromise between metabolic benefit and enzyme cost. This hypothesis and its consequences can be studied by kinetic models in which enzyme profiles are chosen by optimality principles. In enzyme-optimal states, active
Liebermeister, Wolfram
core
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
IFAC-PapersOnLine, 2016 Inspired by great advances on the mathematical structure of chemical reaction networks governed by mass action kinetics and by one of the main features of Irreversible port-Hamiltonian formulation that the thermodynamic principles could be presented clearly and directly in its structure, the aim of our work is to utilize the Irreversible port ...
Wang, Li +2 more
openaire +3 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
An algebraic characterization of self-generating chemical reaction networks using semigroup models
, 2022 Dimitri Loutchko
openalex +2 more sources
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
On the linear stability of some finite difference schemes for nonlinear reaction-diffusion models of chemical reaction networks [PDF]
, 2018 Nathan Muyinda +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Advancing Mathematical Epidemiology and Chemical Reaction Network Theory via Synergies Between Them
EntropyOur paper reviews some key concepts in chemical reaction network theory and mathematical epidemiology, and examines their intersection, with three goals.
Florin Avram, Rim Adenane, Mircea Neagu
doaj +1 more source