Results 131 to 140 of about 136,245 (330)

Interpretation of chemical reaction yields with graph neural additive network

Machine Learning: Science and Technology
Prediction of chemical yields is crucial for exploring untapped chemical reactions and optimizing synthetic pathways for targeted compounds. Recently, graph neural networks have proven successful in achieving high predictive accuracy.
Youngchun Kwon, Yongsik Jung, Youn-Suk Choi, Seokho Kang   +3 more
doaj   +1 more source

Dynamics of Chemical Reaction Networks

, 2022
Network architecture imposes constrains on the types of dynamics a network system admits. Chemical reaction networks have further constrains coming from a special feature of reaction rate functions: the kinetic equations can be written as a product of a ...
Vouffo, Igor
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Chemical Feedback in Templated Reaction-Assembly Networks

, 2020
Chemical feedback between building block synthesis and their subsequent supramolecular self-assembly into nanostructures has profound effects on assembly pathways.
Bos, Inge, Terenzi, Camilla, Sprakel, Joris   +2 more
core   +1 more source

Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis [PDF]

, 2009
An important question in Systems Biology is the design of experiments that enable discrimination between two (or more) competing chemical pathway models or biological mechanisms.
Roper, D., D. Bearup, Chappell, M.J., Evans, N.D., N.D. Evans, Evans, Neil D., Hattersley, J.G., Bugg, T., M.J. Chappell, Dowson, Christopher G., D. Roper, Pérez-Velázquez, J., J.G. Hattersley, T. Bugg, Chappell, M. J. (Michael J.), Bearup, Daniel, Bearup, Daniel James, Dowson, C., Hattersley, John G., J. Pérez-Velázquez, Perez-Velazque, J., Roper, David I., Bugg, Tim, C. Dowson   +23 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding optimal pathways in chemical reaction networks using Ising machines

Physical Review Research
Finding optimal pathways in chemical reaction networks is essential for elucidating and designing chemical processes, with significant applications such as synthesis planning and metabolic pathway analysis.
Yuta Mizuno, Tamiki Komatsuzaki
doaj   +1 more source

Synchronization of Chemical Reaction Networks Based on DNA Strand Displacement Circuits

IEEE Access, 2018
Reversible bimolecular chemical reactions are elementary chemical reactions. This paper investigated this reaction type based on DNA strand displacement, and proposed degradation, catalysis, and annihilation reactions along with the synchronization ...
Chengye Zou, Xiaopeng Wei, Qiang Zhang, Yuan Liu   +3 more
doaj   +1 more source

A Linear Programming Approach to Weak Reversibility and Linear Conjugacy of Chemical Reaction Networks [PDF]

, 2011
Matthew D. Johnston, David Siegel, Gábor Szederkényi   +2 more
openalex   +1 more source