Results 141 to 150 of about 447,849 (263)

Chemoton 2.0: Autonomous Exploration of Chemical Reaction Networks. [PDF]

J Chem Theory Comput, 2022
Unsleber JP, Grimmel SA, Reiher M.
europepmc   +1 more source

Universal slow dynamics of chemical reaction networks

Physical Review E
Understanding the emergent behavior of chemical reaction networks (CRNs) is a fundamental aspect of biology and its origin from inanimate matter. A closed CRN monotonically tends to thermal equilibrium, but when it is opened to external reservoirs, a range of behaviors is possible, including transition to a new equilibrium state, a non-equilibrium ...
Masanari Shimada, Pegah Behrad, Eric De Giuli   +2 more
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Programming and training rate-independent chemical reaction networks. [PDF]

Proc Natl Acad Sci U S A, 2022
Vasić M, Chalk C, Luchsinger A, Khurshid S, Soloveichik D.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A structural approach to understanding enzymatic regulation of chemical reaction networks. [PDF]

Biochem J, 2022
Mochizuki A.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Polynomial superlevel set representation of the multistationarity region of chemical reaction networks. [PDF]

BMC Bioinformatics, 2022
Sadeghimanesh A, England M.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The Similarity Between Epidemiologic Strains, Minimal Self-Replicable Siphons, and Autocatalytic Cores in (Chemical) Reaction Networks: Towards a Unifying Framework

Mathematics
Motivation: We aim to study the boundary stability and persistence of positive odes in mathematical epidemiology models by importing structural tools from chemical reaction networks.
Florin Avram, Rim Adenane, Lasko Basnarkov, Andras Horvath   +3 more
doaj   +1 more source