Results 161 to 170 of about 136,245 (330)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Pathfinder─Navigating and Analyzing Chemical Reaction Networks with an Efficient Graph-Based Approach. [PDF]

J Chem Inf Model, 2023
Türtscher PL, Reiher M.
europepmc   +1 more source

Sufficient Conditions for the Eventual Dying of Reactions in Discrete Chemical Reaction Networks

, 2017
We consider chemical reaction networks operating on discrete state spaces, i.e., where we keep track of molecule counts. We give a sufficient syntactic condition on chemical reaction networks for the impossibility of certain reactions to take place in ...
Brijder, Robert
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Global convergence in systems of differential equations arising from chemical reaction networks [PDF]

, 2013
Mierczynski, J., Banaji, Murad
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

An algebraic characterization of self-generating chemical reaction networks using semigroup models. [PDF]

J Math Biol, 2023
Loutchko D.
europepmc   +1 more source

A dynamical low-rank approach to solve the chemical master equation for biological reaction networks

, 2023
Martina Prugger, Lukas Einkemmer, Carlos F. Lopez   +2 more
openalex   +1 more source

Uniformization techniques for stochastic simulation of chemical reaction networks

, 2019
This work considers the method of uniformization for continuous-time Markov chains in the context of chemical reaction networks. Previous work in the literature has shown that uniformization can be beneficial in the context of time-inhomogeneous models ...
Beentjes, Casper, Ruth E. Baker, Baker, Ruth, Baker, RE, Beentjes, CHL, Casper H. L. Beentjes   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source