Results 221 to 230 of about 1,965,229 (342)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Achieving Pressure Consistency in Mechanochemical Simulations of Chemical Reactions Under Pressure. [PDF]

J Comput Chem
Bentrup J, Weiß R, Zeller F, Neudecker T.   +3 more
europepmc   +1 more source

The Thermodynamic Aspect, the Temperature and the Solvent effects on the Chemical Reactivity of the Darzens Reaction between Isobutyraldehyde and Isopropyl Dibromoacetate: DFT Study.

, 2019
Mohammed El Idrissi
openalex   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Technologies for investigating single-molecule chemical reactions. [PDF]

Natl Sci Rev
Gao C, Gao Q, Zhao C, Huo Y, Zhang Z, Yang J, Jia C, Guo X.   +7 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

3DReact: Geometric Deep Learning for Chemical Reactions. [PDF]

J Chem Inf Model
van Gerwen P, Briling KR, Bunne C, Somnath VR, Laplaza R, Krause A, Corminboeuf C.   +6 more
europepmc   +1 more source

The preparation and chemical reactions of a peracid resin.

, 1974
Ken‐ichi Hirao, O Setoyama, TAKAKO SAITO, Osamu Yonemitsu   +3 more
openalex   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Exploring the Balance between Faradaic and Non-Faradaic Processes in Organic Chemical Reactions at Plasma-Liquid Interfaces. [PDF]

J Am Chem Soc
Bloomquist CK, Naumov D, Yang A, Mathison R, Herzog BD, Tenn WJ, Modestino MA, Aydil ES.   +7 more
europepmc   +1 more source