Results 91 to 100 of about 11,397,539 (252)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

On topological properties of block shift and hierarchical hypercube networks

Open Physics, 2018
Networks play an important role in electrical and electronic engineering. It depends on what area of electrical and electronic engineering, for example there is a lot more abstract mathematics in communication theory and signal processing and networking ...
Guirao Juan Luis García, Siddiqui Muhammad Kamran, Hussain Asif   +2 more
doaj   +1 more source

Local Temperature as a Chemical Reactivity Descriptor

, 2021
Using the electron density and its associated quantities in a molecular system to quantify chemical reactivity in density functional theory is of considerable recent interest. Local temperature based on the kinetic energy density is an intrinsic property
Rong, Chunying, Chattaraj, Pratim Kumar, He, Xin, Liu, Shubin, Guo, Chunna, Lu, Tian   +5 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

RE-IGNITION OF MULTI-SPECIES SOOT CLOUDS IN BUILDING FIRES [PDF]

, 2007
The re-ignition potential of multi-species soot clouds in building fires were investigated based on their extinction characteristics. The investigation was carried out theoretically using an adaptation of Semenov’s thermal explosion theory.
Moghtaderi, B., Poespowati, T.
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Predicting toxicity of triazole fungicide: A molecular-based insight into triadimefon and triadimenol

Results in Chemistry
Background: Triazole fungicides, such as triadimefon (TF) and its stereoisomeric metabolite, triadimenol (TN), remain cornerstone agrochemicals. However, their stereochemistry may affect shape reactivity, intermolecular recognition, and ecotoxicity in ...
Áureo B. Souza, Ronaldo G. Freitas Junior, Ana L.M. Monteiro, Leonardo R. de Almeida, Lucas D. Dias, Lucas B. Ribeiro de Carvalho, Hamilton B. Napolitano, Leonardo L. Borges, Antônio S.N. Aguiar   +8 more
doaj   +1 more source

Conceptual DFT Study of the Local Chemical Reactivity of the Colored BISARG Melanoidin and Its Protonated Derivative

Frontiers in Chemistry, 2018
This computational study assessed eight fixed RSH (range-separated hybrid) density functionals that include CAM-B3LYP, LC-ωPBE, M11, MN12SX, N12SX, ωB97, ωB97X, and ωB97XD related to the Def2TZVP basis sets together with the SMD solvation model in the ...
Juan Frau, Daniel Glossman-Mitnik, Daniel Glossman-Mitnik   +2 more
doaj   +1 more source

Unveiling the reactivity of propargylic hydroperoxides under gold catalysis

, 2013
Controlled gold-catalyzed reactions of primary and secondary propargylic hydroperoxides with a variety of nucleophiles including alcohols, phenols, 2-hydroxynaphthalene-1,4-dione, and indoles allow the direct and efficient synthesis of β-functionalized ...
Alcaide, Benito, Quirós, M. Teresa, Menéndez Rodríguez, María Isabel, López, Ramón, Sochacka Cwikla, Aleksandra, Almendros, Pedro, Sochacka-Cwikla, Alesandra, López Rodríguez, Ramón, Menéndez, María I.   +8 more
core   +1 more source