Results 41 to 50 of about 11,397,539 (252)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Enhanced Chemical Reactivity of Graphene by Fermi Level Modulation
, 2018 Among various approaches to modify the electronic and chemical properties of graphene, functionalization is one of the most facile ways to tailor these properties.
이혁진
core +2 more sources
On statistical evaluation of reverse degree based topological indices for iron telluride networks
Scientific ReportsIn the context of graph theory and chemical graph theory, this research conducts a detailed mathematical investigation of reverse topological indices as they relate to iron telluride networks, clarifying their complex interactions.
Maged Z. Youssef +5 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Information-Theoretic Perspectives on Chemical Problems: Recent Developments and Applications
EntropyInformation-theoretic approach (ITA) has emerged as a powerful density-based framework for interpreting molecular structure, stability, and reactivity within density functional theory (DFT). By treating the electron density as a probability distribution,
Arpita Poddar, Pratim Kumar Chattaraj
doaj +1 more source
Understanding Electronic Structure and Chemical Reactivity: Quantum-Information Perspective
Applied Sciences, 2019 Several applications of quantum mechanics and information theory to chemical reactivity problems are presented with emphasis on equivalence of variational principles for the constrained minima of the system electronic energy and its kinetic energy ...
Roman F. Nalewajski
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Density Functional Theory Study on Chemical Reactivity of Aspirin: Substituent Effect
مجلة بغداد للعلومThere is strong evidence that thrombotic and inflammatory mechanisms play a role in COVID-19 severity. COVID-19 morality may be reduced by common drugs that block these pathways, such as Aspirin. New Aspirin derivatives were suggested by functionalizing
Halah T. Mohammed +4 more
doaj +1 more source
Molecules, 2019 Virotoxins are monocyclic peptides formed by at least five different compounds: alaviroidin, viroisin, deoxoviroisin, viroidin and deoxovirodin. These are toxic peptides singularly found in Amanita virosa mushrooms.
Norma Flores-Holguín +2 more
doaj +1 more source
Chemical Reactivity through Structure-Stability Landscape
, 2014 International audienceThe reactivity descriptors like electronegativity, hardness, and electrophilicity, formulated on conceptual density functional theory can explain chemical reactivity of various acids and bases, oxidants and reductants as well as ...
Das, Ranjita +2 more
core +1 more source