Results 121 to 130 of about 1,129,922 (280)
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna +9 morewiley +1 more sourceEmerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger +3 morewiley +1 more sourceChemical Science moves to weekly issues!
, 2017 Daniel Richards, Antoine Maruani, Vijay Chudasama, Sarit Agasti, Yu Wang, Florian Schueder, Aishwarya Sukumar, Ralf Jungmann, Peng Yin, Young Kim, Yong-Hyun Kim, Yousung Jung, Rong Zhou, Haiwang Liu, Hairong Tao, Xingjian Yu, Jie Wu, Bin Zhang, Lei Ji, Stefanie Griesbeck, Todd Marder, Mohammed Al-Hashimi, Lei Fang, Masato Okazaki, Youhei Takeda, Przemyslaw Data, Piotr Pander, Heather Higginbotham, Andrew Monkman, Satoshi Minakata, Guo-Xing Li, Cristian Morales-Rivera, Fang Gao, Yaxin Wang, Gang He, Peng Liu, Gong Chen, Claire Grison, George Burslem, Jennifer Miles, Ludwig Pilsl, David Yeo, Zeynab Imani, Stuart Warriner, Michael Webb, Andrew Wilson, Franck Le Vaillant, Matthew Wodrich, Jrme Waser, L Candish, M Freitag, T Gensch, F Glorius, Arnau Call, Carla Casadevall, Ferran Acua-Pars, Alicia Casitas, Julio Lloret-Fillol +57 moreopenalex +2 more sourcesGut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte +7 morewiley +1 more sourceBasic Energy Sciences Roundtable: Opportunities for Quantum Computing in Chemical and Materials Sciences
, 2017 Joel E. Moore, Alán Aspuru‐Guzik, Bela Bauer, Sue Coppersmith, Wibe A. de Jong, Thomas Devereaux, Mariví Fernández-Serra, Giulia Galli, Robert J. Harrison, Peter J. Love, Thomas Maier, Antonio Mezzacapo, Jarrod R. McClean, Chris Monroe, John Preskill, Gus Scuseria, K. Birgitta Whaley, James Whitfield, Norman Y. Yao, Dominika Zgid, Bruce C. Garrett, Linda Horton, Jim Murphy, J. M. Davenport, Matthias J. Graf, Jeff Krause, G.N. Maracas, Tom Russell, Ceren Susut-Bennett, Katie Runkles, Brenda Wyatt, Deborah Counce, Kathy Jones +32 moreopenalex +2 more sourcesModeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal +8 morewiley +1 more source
