Results 161 to 170 of about 1,378,218 (287)
Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity
, 2015 This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
Mcdonagh, James, McDonagh, James L.
core
Towards AI Research Agents in the Chemical Sciences
An underlying problem shared by experimental scientists is to achieve optimal behavior of their systems and arrive at new discoveries while searching over an array of controls.
Ofer, Shir
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Voortzetting van: Proceedings of the Academy of Sciences of the USSR.
Academy of sciences of the USSR
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Striving for an Optimal Entry into the Chemical & Pharmaceutical Job Market
CHIMIA, 2020 Romain Dubey +3 more
doaj +1 more source
Innovation in chemical sciences : book of abstracts
Knjiga sadrži sažetke sa simpozija Innovation in chemical ...
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