Results 51 to 60 of about 1,177,372 (244)
STAR ProtocolsSummary: Chiral allenylsilanes serve as crucial intermediates in the synthesis of complex pharmaceutical molecules and natural products. Here, we present a protocol for synthesizing both racemic and chiral allenylsilanes through copper-catalyzed ...
Ying Zhou, Zhengli Liu
doaj +1 more source
The science of mesotherapy: Chemical anarchy [PDF]
Aesthetic Surgery Journal, 2006 The author stresses that to date, the effects of mesotherapy have not been scientifically evaluated. Currently, there is no standardization of dosage and no protocol or treatment algorithm to enable prediction of how much tissue or fat will be "dissolved" with a specific solution in a defined quantity, and injected at a specified subcutaneous tissue ...
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Energy-related Chemical Research at the Universities of Applied sciences
CHIMIA, 2013 An overview of current activities in the field of energy-related chemical research at the Swiss Universities of Applied Sciences is presented.
Wolfgang Riedl +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
iScienceSummary: High chemical stability is of vital significance in rendering metal organic frameworks (MOFs) as promising adsorbents for capturing leaked radioactive nuclides, under real nuclear industrial conditions with high humidity.
Haoyi Tan, Guangcun Shan
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cyphers and cycles – A chemical basis of the differential attraction of mosquitoes to human odor
iScienceSummary: Anthropophilic mosquitoes, such as the yellow fever mosquito, Aedes aegypti, not only exhibit a robust host preference for humans but are also known to favor certain individuals over others, which has been attributed to variations in individual ...
Annika Hinze +6 more
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