Results 91 to 100 of about 576,391 (278)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Wearable bio and chemical sensors [PDF]

, 2014
Chemical and biochemical sensors have experienced tremendous growth in the past decade due to advances in material chemistry combined with the emergence of digital communication technologies and wireless sensor networks (WSNs) [1].
Anoshkin, Ataman, Badugu, Bandodkar, Bergmann, Bhandari, Byrne, Chandrasekhar, Chen, Chu, Claramunt, Coyle, Coyle, Coyle, Curto, Curto, Derbyshire, Gerard, Guinovart, Hill, Jia, Khodagholy, Kim, Kinkeldei, Li, Li, Lima, Lobnik, Mannoor, Massie, Miller, Miller, Morris, Nilghaz, Nilghaz, Ohashi, Oncescu, O’Mahony, Papacosta, Patterson, Potyrailo, Rebrin, Reches, Sakaguchi, Schazmann, Strambini, Suzuki, Voirin, Whitesides, Windmiller, Xing, Yang   +51 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Quantitative measurement of combustion gases in harsh environments using NDIR spectroscopy

, 2018
The global climate change calls for a more environmental friendly use of energy and has led to stricter limits and regulations for the emissions of various greenhouse gases.
Bauke, Stephan, Ctistis, Georgios, Golibrzuch, Kai, Müller, Fabian, Niklas, Christian, Wackerbarth, Hainer   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Detection Methodologies for Pathogen and Toxins: A Review

Sensors, 2017
Pathogen and toxin-contaminated foods and beverages are a major source of illnesses, even death, and have a significant economic impact worldwide. Human health is always under a potential threat, including from biological warfare, due to these dangerous ...
Md Eshrat E. Alahi, Subhas Chandra Mukhopadhyay   +1 more
doaj   +1 more source

Monitoring vegetation dynamics from lunar orbiting satellites [PDF]

, 2018
PresentationFUNCTION STATEMENT: Our analyses are based on data from Terra MISR/MODIS, Aqua MODIS, DSCIVR EPIC and EO-1 Hyperion sensors. Science questions as identified in NASA’s Science Plan: Detect and predict changes in Earth’s ecological and ...
Knyazikhin, Yuri, Park, Taejin, Xu, Baodong   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors

Sensors
The goal of the sensor industry is to develop innovative, energy-efficient, and reliable devices to detect molecules relevant to economically important sectors such as clinical diagnoses, environmental monitoring, food safety, and wearables.
Selene Acosta, Mildred Quintana
doaj   +1 more source