Results 1 to 10 of about 8,888,554 (384)

Chemical Synthesis of Human Proteoforms and Application in Biomedicine. [PDF]

ACS Cent Sci
Limited understanding of human proteoforms with complex posttranslational modifications and the underlying mechanisms poses a major obstacle to research on human health and disease.
Ai H, Pan M, Liu L.
europepmc   +2 more sources

An automatic end-to-end chemical synthesis development platform powered by large language models. [PDF]

Nat Commun
The rapid emergence of large language model (LLM) technology presents promising opportunities to facilitate the development of synthetic reactions. In this work, we leveraged the power of GPT-4 to build an LLM-based reaction development framework (LLM ...
Ruan Y, Lu C, Xu N, He Y, Chen Y, Zhang J, Xuan J, Pan J, Fang Q, Gao H, Shen X, Ye N, Zhang Q, Mo Y.   +13 more
europepmc   +2 more sources

Novel protein science enabled by total chemical synthesis [PDF]

Protein Science, 2018
Chemical synthesis is a well‐established method for the preparation in the research laboratory of multiple‐tens‐of‐milligram amounts of correctly folded, high purity protein molecules.
Stephen B. H. Kent
openalex   +2 more sources

DigiChemTree enables programmable light-induced carbene generation for on demand chemical synthesis [PDF]

Communications Chemistry
The reproducibility of chemical reactions, when obtaining protocols from literature or databases, is highly challenging for academicians, industry professionals and even now for the machine learning process.
Abhilash Rana, Ruchi Chauhan, Amirreza Mottafegh, Dong Pyo Kim, Ajay K. Singh   +4 more
doaj   +2 more sources

Approaches to the Total Synthesis of Conduramines: A Review

SynOpen, 2022
This review reports on the total synthesis of conduramines, which are formally derived from conduritols, mainly containing a trihydroxy aminocyclohexene core.
Hanumantharayappa Bharathkumar, Jattuboyina Siva Krishna, Banothu Surender, Venkateswara Rao Batchu   +3 more
doaj   +1 more source

Direct Bottom-Up In Situ Growth: A Paradigm Shift for Studies in Wet-Chemical Synthesis of Gold Nanoparticles

Chemical Reviews, 2023
Plasmonic gold nanoparticles have been used increasingly in solid-state systems because of their applicability in fabricating novel sensors, heterogeneous catalysts, metamaterials, and thermoplasmonic substrates.
Gail A. Vinnacombe-Willson, Ylli Conti, Andrei Stefancu, Paul S. Weiss, E. Cortes, Leonardo Scarabelli   +5 more
semanticscholar   +1 more source

The Chemical Synthesis of the Crinine and Haemanthamine Alkaloids: Biologically Active and Enantiomerically-Related Systems that Serve as Vehicles for Showcasing New Methodologies for Molecular Assembly

Molecules, 2021
The title alkaloids, often referred to collectively as crinines, are a prominent group of structurally distinct natural products with additional members being reported on a regular basis. As such, and because of their often notable biological properties,
Nan Hu, Lorenzo V. White, Ping Lan, Martin G. Banwell   +3 more
doaj   +1 more source

Double boron–oxygen-fused polycyclic aromatic hydrocarbons: skeletal editing and applications as organic optoelectronic materials

Nature Communications, 2023
An efficient one-pot strategy for the facile synthesis of double boron–oxygen-fused polycyclic aromatic hydrocarbons (dBO-PAHs) with high regioselectivity and efficient skeletal editing is developed.
Guijie Li, Kewei Xu, Jianbing Zheng, Xiaoli Fang, Yun-Fang Yang, Weiwei Lou, Qingshan Chu, Jianxin Dai, Qidong Chen, Yuning Yang, Yuan-Bin She   +10 more
doaj   +1 more source

Practical, Multigram Preparation of Synthetically Useful, Enantiomerically Pure Building-Blocks from Quinic Acid

SynOpen, 2022
The naturally abundant, enantiomerically pure cyclitol quinic acid has been converted into a synthetically useful enone in nearly quantitative yield using the operationally straightforward and reproducible protocols reported herein.
Shen Tan, Ping Lan, Martin G. Banwell, Lorenzo V. White   +3 more
doaj   +1 more source

Atomically dispersed Cu coordinated Rh metallene arrays for simultaneously electrochemical aniline synthesis and biomass upgrading

Nature Communications, 2023
Organic electrocatalytic conversion is an essential pathway for the green conversion of low-cost organic compounds to high-value chemicals, which urgently demands the development of efficient electrocatalysts.
Qiqi Mao, Xu Mu, Wenxin Wang, Kai Deng, Hongjie Yu, Ziqiang Wang, You Xu, Liang Wang, Hongjing Wang   +8 more
doaj   +1 more source