Results 171 to 180 of about 958,825 (298)

Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor

open access: green, 2013
José Roberto Santin   +12 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Discovery of hybrid chemical synthesis pathways with DORAnet.

open access: yesDigit Discov
Zhang Q   +5 more
europepmc   +1 more source

A 13-Oxo-9,10-epoxytridecenoate Phospholipid Analogue of the Genotoxic 4,5-Epoxy-2E-decenal: Detection in Vivo, Chemical Synthesis, and Adduction with DNA

open access: green, 2010
Clementina Mesaros   +7 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

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