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The chemical synthesis of proteins
Current Opinion in Biotechnology, 1993Total chemical synthesis is developing as an important approach to the construction of native proteins and their analogs for the study of the structural basis of biochemical activity. In the past year, a radical departure from conventional synthetic approaches has led to a renaissance in this field. The inherent simplicity of these new modes of protein
T W, Muir, S B, Kent
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Chemical Synthesis of the Englerins
Chemistry – An Asian Journal, 2011AbstractIn the long lasting battle against cancer, Nature sometimes gives a helping hand to researchers to find new drugs for the treatment of diseases and improvement of patients′ well‐being. Englerin A has emerged as a promising anticancer candidate as well as being an exciting synthetic challenge for organic chemists.
Pouwer, Rebecca +3 more
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Chemical Synthesis of Glycosaminoglycans
Chemical Reviews, 2016Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many essential biological cell processes, as well as in many courses of diseases. Because of the potential therapeutic application of GAG polymers, fragments, and also derivatives toward different diseases (e.g., heparin derivatives against Alzheimer's disease), there is a ...
Mende, Marco +6 more
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Chemical Synthesis of Saponins
2014Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in plants and some marine organisms. By expressing a large diversity of structures on both sugar chains and aglycones, saponins exhibit a wide range of biological and pharmacological properties and serve as major active principles in folk medicines, especially in ...
You, Yang, Stephane, Laval, Biao, Yu
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Chemical Synthesis of Gangliosides
2023Synthetic methodologies for gangliosides have evolved over the past three decades. The strategies for constructing ganglioside skeletons can generally be classified as late-stage ceramide coupling, the glucosyl ceramide cassette strategy, or late-stage sialylation.
Akihiro, Imamura +2 more
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Chemical Synthesis of Polysaccharides
1967Publisher Summary This chapter discusses the chemical synthesis of polysaccharides. The present concepts of the chemical constitution of such important biopolymers ascellulose, amylose, and chitin can be confirmed by their adequate chemical synthesis.
I J, Goldstein, T L, Hullar
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Enzymes for chemical synthesis
Nature, 2001New catalytic synthetic methods in organic chemistry that satisfy increasingly stringent environmental constraints are in great demand by the pharmaceutical and chemical industries. In addition, novel catalytic procedures are necessary to produce the emerging classes of organic compounds that are becoming the targets of molecular and biomedical ...
K M, Koeller, C H, Wong
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Chemical Synthesis of Phosphatidylglucoside
20231-stearoyl (18:0)-2-arachidoyl (20:0)-sn-glycero-3-phospho-ß-D-glucoside (Phosphatidylglucoside or PtdGlc) was synthesized by direct coupling of D-glucose with the phosphate group of phosphatidic acid (18:0, 20:0). Selective in situ activation of the anomeric center of D-glucose by 2-chloro-1,3-dimethylimidazolinium chloride (DMC) in aqueous media ...
Koki, Kano +3 more
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Chemical synthesis of proteins
Trends in Biotechnology, 2000The manipulation of protein structure enables a better understanding of the principles of protein folding, as well as the development of novel therapeutics and drug-delivery vehicles. Chemical synthesis is the most powerful approach for constructing proteins of novel design and structure, allowing for variation of covalent structure without limitations.
J A, Borgia, G B, Fields
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Chemical Synthesis in Microreactors
2009To develop a new generation of drugs, pharmaceutical companies need to be able to synthesise and screen novel chemicals with enhanced speed. New technology that would enable a cost neutral step change in the number of potential drug candidates would provide a distinct competitive advantage.
Paul, Watts, Stephen J, Haswell
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