Results 271 to 280 of about 958,825 (298)
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Chemical synthesis of proteins
Chemistry & Biology, 1994Powerful new enzymatic and chemical methods for coupling unprotected peptide fragments are making the assembly of large synthetic proteins possible. By allowing the use of novel backbones and the incorporation of multiple unnatural amino acids at specific sites, these methods promise large expansion of the repertoire of protein molecules accessible to ...
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Current Opinion in Biotechnology, 1998
Chemical protein synthesis is a field in transition. Previously, the synthetic accomplishment itself was the major focus of work in this field. Increasingly, chemical synthesis is now being applied to understanding how biological function originates in the structure of the protein molecule.
J, Wilken, S B, Kent
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Chemical protein synthesis is a field in transition. Previously, the synthetic accomplishment itself was the major focus of work in this field. Increasingly, chemical synthesis is now being applied to understanding how biological function originates in the structure of the protein molecule.
J, Wilken, S B, Kent
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Chemical Synthesis of Endotoxin
1990Total synthesis of lipid A’s of Escherichia coli and many other bacterial species achieved in our laboratory (6, 7, 8) contributed not only to confirm their proposed chemical structures but also to establish unequivocally that these phosphorylated polyacyl glucosamine disaccharide with definite structures are responsible for most of the endotoxic ...
S, Kusumoto +4 more
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Chemical Synthesis of Polynucleotides
Angewandte Chemie International Edition in English, 1972AbstractCurrent methodology for the chemical synthesis of short chains (up to about twenty nucleotide units) of deoxyribopolynucleotides is reviewed.
K L, Agarwal +3 more
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The Chemical Synthesis of Discodermolide
2008The marine sponge-derived polyketide discodermolide is a potent antimitotic agent that represents a promising natural product lead structure in the treatment of cancer. Discodermolide shares the same microtubule-stabilising mechanism of action as Taxol(®), inhibits the growth of solid tumours in animal models and shows synergy with Taxol.
I, Paterson, G J, Florence
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The chemical synthesis of a phosphatidylglucose
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970Abstract A condensation reaction between the silver salt of 1-myristoyl-2-oleoyl-sn-glycerol-3-(monobenzyl) phosphate and 1- bromo -1- deoxy -2,3,4,6- tetra -O- acetyl -α- d gluco-pyranose yielded, after removal of the blocking groups, β- d -glucopyranosyl-(1-myristoyl-2-oleoyl-sn-glycero-3-phosphate).
H M, Verheij +3 more
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Chemical Synthesis of the Trichothecenes
1985That research in the trichothecene field is an area of intense interest cannot be disputed. In the years 1982 and 1983, there were more than 500 publications dealing with this subject, including more than 30 reviews. In addition, a comprehensive monograph has recently appeared (151).
P G, McDougal, N R, Schmuff
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Current Opinion in Chemical Biology, 1999
Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid ...
G G, Kochendoerfer, S B, Kent
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Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid ...
G G, Kochendoerfer, S B, Kent
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Chemical Synthesis of Gangliosides
2018Various methods for the chemical synthesis of gangliosides have been investigated to date and numerous natural gangliosides and their structural analogues have been synthesized during the past three decades. Key technologies in the synthesis of gangliosides include α-selective sialylation and introduction of the ceramide moiety into the oligosaccharide
Akihiro, Imamura, Makoto, Kiso
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