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Chemical synthesis of polysaccharides
Current Opinion in Chemical Biology, 2022Here we summarize the chemical syntheses of glycans containing over 20 monosaccharide units, with the recent syntheses of ultra-long glycans, including a 92mer arabinogalactan, a 100mer and a 151mer mannan, and a 128mer rhamnomannan, being highlighted. The assembly strategies, glycosylation methods, and protecting group manipulations, which are crucial
Shengyang, Wang +4 more
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Chemical Synthesis of Single Atomic Site Catalysts.
Chemical Reviews, 2020Manipulating metal atoms in a controllable way for the synthesis of materials with the desired structure and properties is the holy grail of chemical synthesis.
Shufang Ji +5 more
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The Chemical Synthesis of Insulin: An Enduring Challenge.
Chemical Reviews, 2021The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly, type 2 diabetes.
J. Karas, J. Wade, M. Hossain
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Current Opinion in Biotechnology, 1998
Chemical protein synthesis is a field in transition. Previously, the synthetic accomplishment itself was the major focus of work in this field. Increasingly, chemical synthesis is now being applied to understanding how biological function originates in the structure of the protein molecule.
J, Wilken, S B, Kent
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Chemical protein synthesis is a field in transition. Previously, the synthetic accomplishment itself was the major focus of work in this field. Increasingly, chemical synthesis is now being applied to understanding how biological function originates in the structure of the protein molecule.
J, Wilken, S B, Kent
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Current Opinion in Chemical Biology, 1999
Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid ...
G G, Kochendoerfer, S B, Kent
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Since the mid-1990s, chemical synthesis has emerged as a powerful technique for the study of structure/function relationships in proteins. During the review period, the applicability of chemical protein synthesis techniques has been significantly broadened by increases in the size of synthetically accessible proteins through two new techniques: solid ...
G G, Kochendoerfer, S B, Kent
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Chemical Synthesis and Biological Application of Modified Oligonucleotides.
Bioconjugate chemistry, 2020RNA plays a myriad of roles in the body including the coding, decoding, regulation and expression of genes. RNA oligonucleotides have garnered significant interest as therapeutics via antisense oligonucleotides or small interfering RNA strategies for the
Daniel A. Glazier +6 more
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Crystal Phase Control of Gold Nanomaterials by Wet-Chemical Synthesis.
Accounts of Chemical Research, 2020ConspectusGold (Au), a transition metal with an atomic number of 79 in the periodic table of elements, was discovered in approximately 3000 B.C. Due to the ultrahigh chemical stability and brilliant golden color, Au had long been thought to be a most ...
Shiyao Lu +9 more
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Chemical Synthesis of Saponins
2014Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in plants and some marine organisms. By expressing a large diversity of structures on both sugar chains and aglycones, saponins exhibit a wide range of biological and pharmacological properties and serve as major active principles in folk medicines, especially in ...
You, Yang, Stephane, Laval, Biao, Yu
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Chemical Synthesis of Gangliosides
2023Synthetic methodologies for gangliosides have evolved over the past three decades. The strategies for constructing ganglioside skeletons can generally be classified as late-stage ceramide coupling, the glucosyl ceramide cassette strategy, or late-stage sialylation.
Akihiro, Imamura +2 more
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Chemical Synthesis of Glycosaminoglycans
Chemical Reviews, 2016Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many essential biological cell processes, as well as in many courses of diseases. Because of the potential therapeutic application of GAG polymers, fragments, and also derivatives toward different diseases (e.g., heparin derivatives against Alzheimer's disease), there is a ...
Mende, Marco +6 more
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