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Chemical synthesis of proteins
Chemistry & Biology, 1994Powerful new enzymatic and chemical methods for coupling unprotected peptide fragments are making the assembly of large synthetic proteins possible. By allowing the use of novel backbones and the incorporation of multiple unnatural amino acids at specific sites, these methods promise large expansion of the repertoire of protein molecules accessible to ...
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The Journey for the Total Chemical Synthesis of a 53 kDa Protein.
Accounts of Chemical Research, 2019Chemical protein synthesis has been proved as an efficient way to afford medium-sized proteins with high homogeneity in workable quantities for various biochemical, structural, and functional studies. In particular, chemical protein synthesis has enabled
Hao Sun, A. Brik
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Total Chemical Synthesis of Crambin
Journal of the American Chemical Society, 2004Crambin is a small (46 amino acids) protein isolated from the seeds of the plant Crambe abyssinica. Crambin has been extensively used as a model protein for the development of advanced crystallography and NMR techniques and for computational folding studies. We set out to establish synthetic access to crambin.
Duhee, Bang +2 more
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Bayesian reaction optimization as a tool for chemical synthesis
Nature, 2021Benjamin J. Shields +8 more
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Chemical Synthesis of Gangliosides
2018Various methods for the chemical synthesis of gangliosides have been investigated to date and numerous natural gangliosides and their structural analogues have been synthesized during the past three decades. Key technologies in the synthesis of gangliosides include α-selective sialylation and introduction of the ceramide moiety into the oligosaccharide
Akihiro, Imamura, Makoto, Kiso
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An autonomous portable platform for universal chemical synthesis
Nature Chemistry, 2022J. S. Manzano +6 more
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Automation and computer-assisted planning for chemical synthesis
Nature Reviews Methods Primers, 2021Yuning Shen +5 more
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Chemical synthesis of sphingolipids
Journal of the American Oil Chemists' Society, 1965AbstractThe chemical synthesis of sphingosine, derivatives of sphingosine, and sphingolipids are reviewed.
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