Results 41 to 50 of about 1,800,080 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Noxological challenges of technogenic society: socio-philosophical aspect

Семиотические исследования
With the development of a technogenic society, security issues are becoming increasingly important both in relation to existing technologies and in assessing potential threats associated with the development of technology and technological systems, that ...
Anna F. Gordova, Nikolay M. Tverdynin
doaj   +1 more source

Innovative technologies for chemical security

Pure and Applied Chemistry, 2018
AbstractAdvances across the chemical and biological (life) sciences are increasingly enabled by ideas and tools from sectors outside these disciplines, with information and communication technologies playing a key role across 21stcentury scientific development.
Jonathan E. Forman, Christopher M. Timperley, Pål Aas, Mohammad Abdollahi, Isel Pascual Alonso, Augustin Baulig, Renate Becker-Arnold, Veronica Borrett, Flerida A. Cariño, Christophe Curty, David Gonzalez, Zrinka Kovarik, Roberto Martínez-Álvarez, Robert Mikulak, Evandro de Souza Nogueria, Ponnadurai Ramasami, Syed K. Raza, Ahmed E. M. Saeed, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Farhat Waqar, Volodymyr Zaitsev, Mongia Saïd Zina, Katarína Grolmusová, Guy Valente, Marlene Payva, Siqing Sun, Amy Yang, Darcy van Eerten   +30 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Role of mathematics in chemistry and chemical technology

Тонкие химические технологии, 2010
A number of aspects determining the role of classical and applied mathematics in natural and applied sciences, particularly, in chemistry and chemical technology is considered.
L. A. Serafimov, A. K. Frolkova, V. S. Timofeev   +2 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Analysis on application status of CCUS technology in emission reduction of modern coal chemical project in chemical industry [PDF]

E3S Web of Conferences
To gain a deeper understanding of the current application status of carbon capture, utilization, and storage (CCUS) technology in modern coal chemical projects aimed at reducing emissions in the chemical industry, a study on the application of CCUS ...
Zhan Yu
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Uses of Chemical Technologies for Meat Decontamination

Food Science of Animal Resources
Traditional meat preservation techniques such as smoking, drying, and salting have various shortcomings and limitations in effectively reducing microbial loads and maintaining meat quality.
Donggyun Yim
doaj   +1 more source

Research on Science and Technology Level of Chemical Industry in China based on the Perspective of Talent Innovation Ability -a Case Study of Yangtze River Delta in China

Chemical Engineering Transactions, 2017
At present, there is no industry without chemicals. Without the chemical industry, the economy and society can hardly maintain rapid growth. However, there are some problems in the development of chemical industry such as low chemical technology and slow
Nanbing Xiao
doaj   +1 more source