Results 181 to 190 of about 111,464 (290)

Global Bias-Aware Synthesis of Meta-Analyses Reveals Agroforestry's Potential for Improving Soil Health. [PDF]

Glob Chang Biol
Camille Manon R, Damien B, Margret K, Johan S, Florian W, Andrea S, Sonja K.   +6 more
europepmc   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

AGAPE (Computational G‑Quadruplex Stabilization Prediction): The First Machine Learning Workflow for G‑Quadruplex Stabilization Prediction. [PDF]

ACS Omega
D'Anna L, Contino S, Marinello R, Fares J, De Simone G, Monari A, Barbault F, Barone G, Terenzi A, Perricone U.   +9 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

A long-term ecosystem monitoring dataset from the ICP Integrated Monitoring network: biogeochemical data from 1977-2020 across 14 European countries. [PDF]

Sci Data
Weldon J, Aas W, Albiniak B, Augustaitis A, Baužienė I, Capelli C, Clarke N, Cummins T, de Wit HA, Dirnböck T, Djukic I, Eklöf K, Forsius M, Futter M, Grandin U, Gromov S, Šmejkalová AH, Ibañez R, Indriksone I, Jutterström S, Kobler J, Koger H, Kölbl A, Kostrzewski A, Koukhta A, Krám P, Kruszyk R, Lasheras E, Lõhmus K, Majewski M, Makkonen U, Markensten H, Miranda R, Mirtl M, Moldan F, Papitto G, Peterseil J, Pivoras A, Plha T, Pröll G, Rönnback P, Santamaría C, Santamaría JM, Skotak K, Elustondo D, Valerio M, Venier S, Vlaar LE, Ukonmaanaho L, Vuorenmaa J, Wellbrock N.   +50 more
europepmc   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Growth Characteristics of Electro-Water Mixed Branches in Acid-Base Solution Based on Frequency Dielectric Spectroscopy Analysis. [PDF]

Polymers (Basel)
Li S, Zhu B, Zhang X, Yang B.
europepmc   +1 more source

Synergistic Enhancement of Electrical‐Thermal Properties in KH550/G‐POSS Functionalized BN/Epoxy Composites for High‐Frequency Transformer Insulation

Advanced Science, EarlyView.
A BN@G‐POSS/EP nanocomposite is developed for high‐frequency transformer insulation in power electronic transformers. Through synergistic interface engineering, it simultaneously enhances thermal conductivity, reduces viscosity, and improves electro‐thermal stability.
Jun Jiang, Shaojie Luo, Dezhi Cui, Zeya Huang, Shuai Jiang, Renli Fu, Yuan Wang   +6 more
wiley   +1 more source

Evaluation of copper chloride crystallisation as a method for systems-level characterisation of phytopharmaceuticals - a pilot investigation. [PDF]

Sci Rep
Guglielmetti G, Doesburg P, Scherr C, Martin D, Baumgartner S, Tournier AL.   +5 more
europepmc   +1 more source