Results 121 to 130 of about 39,906 (300)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On the formation and evolution of magnetic chemically peculiar stars in the solar neighborhood

, 2005
In order to put strict observational constraints on the evolutionary status of the magnetic chemically peculiar stars (CP2) of the upper main sequence, we have investigated a well established sample of galactic field CP2 objects within a radius of 200pc ...
Abt, Adelman, Allende Prieto, Bagnulo, Bychkov, Catalano, Chen, Crawford, Crawford, Dutra, E. Paunzen, Flower, Glagolevskij, Glagolevskij, Golay, Gómez, H. M. Maitzen, H. Pöhnl, Hauck, Hauck, Hilditch, Hubrig, Künzli, Lanz, Lutz, Mermilliod, Moss, Napiwotzki, Nishimura, North, North, Paunzen, Paunzen, Preston, Pöhnl, Renson, Schaerer, Schaller, Smalley   +38 more
core   +1 more source

Atomic diffusion in magnetic chemically peculiar stars

, 2021
Atomic diffusion in stars may affect element distributions in layers where mixing motions are weak enough. Stars for which abundance distributions are clearly inhomogeneous (outside the core), and that are considered having abundances strongly abnormal in their atmosphere, are the chemically peculiar stars of the main-sequence.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Carbon Stars from Gaia Data Release 3 and the Space Density of Dwarf Carbon Stars

The Astrophysical Journal
Carbon stars (with atmospheric C/O > 1) range widely in temperature and luminosity, from low-mass dwarfs to asymptotic giant branch (AGB) stars. The main-sequence dwarf carbon (dC) stars have inherited carbon-rich material from an AGB companion, which ...
Benjamin R. Roulston, Naunet Leonhardes-Barboza, Paul J. Green, Evan Portnoi   +3 more
doaj   +1 more source

The link between symbiotic stars and chemically-peculiar red giants [PDF]

, 2002
Barium stars and technetium-poor, extrinsic S stars are binary systems with a white dwarf companion, and with orbital elements similar to those of symbiotic systems. One may thus wonder whether these various families of binary systems involving red giant
Jorissen, A.
core   +1 more source

Abundance and stratification analysis of the CP star HD 103498

, 2011
Slow rotation and absence of strong mixing processes in atmospheres of chemically peculiar stars develop ideal conditions for the appearance of abundance anomalies through the mechanism of microscopic particle diffusion.
Alecian, Alecian, Amôres, Anderson, Asplund, Auriére, Berry, Bessell, Blanco, Chhavi P. Pandey, Denis V. Shulyak, Hauck, Huchra, Joshi, Kaiser, Kochukhov, Kochukhov, Kochukhov, Kupka, Kurucz, LeBlanc, Lincke, Matheron, Michaud, Oleg Kochukhov, Paunzen, Piskunov, Przybilla, Rufener, Rufener, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Shulyak, Shulyak, Shulyak, Skrutskie, Smith, Tanya Ryabchikova, Tsymbal, van der Bliek, van Leeuwen   +43 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Chemically Peculiar Stars Among Spectroscopic Binaries – Revisited [PDF]

International Astronomical Union Colloquium, 1993
AbstractThis paper presents a new statistical investigation of peculiar A-type stars (Am, Ap, Hg-Mn) among spectroscopic binary (SB) stars. The relative frequency of Am (CP 1) stars is 55% in the spectral range A1 to A6 of main-sequence stars. The Ap (CP 2) stars amount to 15% in the range B9 to A2.
openaire   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source