Results 61 to 70 of about 1,282,798 (237)
International Journal of Occupational Medicine and Environmental Health, 2013 The aim of this review was to investigate the association between attention defi cit / hyperactivity disorder (ADHD) or ADHD- related symptoms and industrial chemicals, such as organophosphates and organochlorine pesticides, polychlorinated biphenyls ...
Kinga Polańska +2 more
doaj +1 more source
Predicting Chemical Toxicity Effects Based on Chemical-Chemical Interactions
PLoS ONE, 2013 Toxicity is a major contributor to high attrition rates of new chemical entities in drug discoveries. In this study, an order-classifier was built to predict a series of toxic effects based on data concerning chemical-chemical interactions under the assumption that interactive compounds are more likely to share similar toxicity profiles.
Lei Chen +5 more
openaire +4 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Frontiers in Genetics, 2018 The TempO-SeqTM platform allows for targeted transcriptomic analysis and is currently used by many groups to perform high-throughput gene expression analysis.
Pierre R. Bushel +2 more
doaj +1 more source
Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. [PDF]
, 2006 Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first ...
Axelrad, Daniel +4 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
CHEMICALS AS OCCUPATIONAL RISK FACTORS FOR TYPE 2 DIABETES
Arta Medica, 2020 Objectives. Diabetes mellitus is one of the most serious socio-economic, medico-social and demographic problems, characterized by a chronic evolution, a tendency to progress and the development of complications.
Vladimir Bebîh, Vladimir Bernic
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Toxic Chemicals (title provided or enhanced by cataloger) [PDF]
This lesson introduces students to the concept of toxic chemicals. Topics include a definition of the term 'toxic', factors that can affect the potential for a chemical to be harmful, and a brief overview of federal agencies that have authority to ...
Chris Fox
core