Results 241 to 250 of about 423,426 (288)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

An electrophoretic mobility shift assay with chemiluminescent readout to evaluate DNA-targeting oligonucleotide-based probes. [PDF]

PLoS One
Everly ME, Wieber PJ, Al Janabi I, Hrdlicka PJ.   +3 more
europepmc   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Exploiting the Clinical Potential of a Chemiluminescent Probe for <i>Mycoplasma pneumoniae</i> Diagnosis. [PDF]

Chem Biomed Imaging
Jiao Y, Cao Z, Liu Y, Xiong A, Zhao H, Wang G, Dong J, Shi X, Shi K, Sun B, Guo J, Lv P, Zhao Z.   +12 more
europepmc   +1 more source

AuNP-Containing Hydrogels Based on Arabinogalactan and κ-Carrageenan with Antiradical Activity. [PDF]

Gels
Zvereva M.
europepmc   +1 more source

A new, rapid, chemiluminescence enzyme assay for the detection of heparin-induced thrombocytopenia: a comparison between functional and immune heparin-induced thrombocytopenia assays. [PDF]

Res Pract Thromb Haemost
Bowyer A, Kohama K, Patel I, Kobayashi K, Hasegawa R, Mukaida A, Greinacher A, Kitchen S.   +7 more
europepmc   +1 more source

Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated With Ascending Colon Cancer Expressing Aquaporin-4 and Glucose-Regulated Protein 78. [PDF]

Cureus
Iwamoto R, Nakada R, Sato R, Miyagawa S, Shimizu F.   +4 more
europepmc   +1 more source

Distributed multitudes of bio-inspired, biodegradable Lagrangian sensors for environmental sustainability. [PDF]

Nat Commun
Park C, Hu Z, Li K, Kim JT, Rogers JA.
europepmc   +1 more source