Results 241 to 250 of about 426,746 (287)

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Data showing effects of resolvin D₅ on prostaglandin E₂ mediated inhibition of fMet-Leu-Phe induced activation of the NADPH oxidase in human neutrophils. [PDF]

Data Brief
Li W, Dahlgren C, Forsman H.
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis. [PDF]

World J Gastroenterol
Bouayad A.
europepmc   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Chemiluminescent 2-Coumaranones: Synthesis, Luminescence Mechanism, and Emerging Applications. [PDF]

Molecules
Schramm S, Lippold T, Navizet I.
europepmc   +1 more source

Magnetic Particle-Based Automated Chemiluminescence Immunoassay for the Determination of Hydrocortisone Residues in Milk. [PDF]

Foods
Yang YY, Jia BZ, Xu ZL, Liu YX, Luo L.
europepmc   +1 more source

Anticodon Engineered Transfer RNA (tRNA^SUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein. [PDF]

Adv Sci (Weinh)
Yang X, Sun H, Luo Z, Zhang Q, Song Y, Li J, Liu X, Wang J.   +7 more
europepmc   +1 more source

Development of Single-Molecule Enzyme Activity Assay for Serine Hydrolases Using Activity-Based Protein Labeling Probes. [PDF]

Small Methods
Ishii S, Minoda M, Mizuno T, Iwasaka T, Kusuhara H, Honda K, Urano Y, Komatsu T.   +7 more
europepmc   +1 more source