Results 1 to 10 of about 273,083 (353)
Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators
JID Innovations, 2023 Psoriasis is characterized by intense pruritus, with a subset of individuals with psoriasis experiencing thermal hypersensitivity. However, the pathophysiology of thermal hypersensitivity in psoriasis and other skin conditions remains enigmatic. Linoleic
Joshua J. Wheeler +7 more
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Frontiers in Pain Research, 2023 BackgroundMigraine is a prevalent disabling condition often associated with comorbid physical and psychological symptoms that contribute to impaired quality of life and disability.
Keturah R. Faurot +15 more
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Acta Neuropathologica Communications, 2023 In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease.
Christopher E. Ramsden +11 more
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Journal of Lipid Research, 2023 Natural variations in the 13C:12C ratio (carbon-13 isotopic abundance [δ13C]) of the food supply have been used to determine the dietary origin and metabolism of fatty acids, especially in the n-3 PUFA biosynthesis pathway.
Daniel K. Chen +10 more
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Cell Death via Lipid Peroxidation and Protein Aggregation Diseases
Biology, 2021 Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi +2 more
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Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons
Neurobiology of Pain, 2020 Endogenous lipid mediators are proposed to contribute to headache and facial pain by activating trigeminal neurons (TN). We recently identified 11-hydroxy-epoxide- and 11-keto-epoxide derivatives of linoleic acid (LA) that are present in human skin and ...
Suzanne Doolen +2 more
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Cell Death Discovery, 2022 Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze +2 more
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Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration
Neural Regeneration Research, 2023 Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders.
Irene Villalón-García +10 more
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The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]
, 2012 Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana +8 more
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Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage
Antioxidants, 2020 Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety.
Rafael Félix +5 more
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