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Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

Cell Death and Disease
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms.
Yongxin Zheng, Junlu Sun, Zhiting Luo, Yimin Li, Yongbo Huang   +4 more
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Lipid peroxidation of immune cells in cancer

Frontiers in Immunology
Growing evidence indicates that cellular metabolism is a critical determinant of immune cell viability and function in antitumor immunity and lipid metabolism is important for immune cell activation and adaptation to the tumor microenvironment (TME ...
Liuling Xiao, Miao Xian, Chuanchao Zhang, Qi Guo, Qing Yi   +4 more
doaj   +1 more source

Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain

Acta Neuropathologica Communications, 2022
Lipid peroxidation is a process of oxidative degradation of cellular lipids that is increasingly recognized as an important factor in the pathogenesis of neurodegenerative diseases.
YuHong Fu, Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, Ping Wu, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim   +8 more
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Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes

Redox Biology, 2018
Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to the pre-exposure state.
Aron B. Fisher, Jose P. Vasquez-Medina, Chandra Dodia, Elena M. Sorokina, Jian-Qin Tao, Sheldon I. Feinstein   +5 more
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CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease

Redox Biology, 2020
The oxidative degradation of lipids has been shown to be implicated in the progression of several neurodegenerative diseases and modulating lipid peroxidation may be efficacious for treating Alzheimer’s disease (AD).
Gamze Ates, Joshua Goldberg, Antonio Currais, Pamela Maher   +3 more
doaj   +1 more source

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene[S]

Journal of Lipid Research, 2015
Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting in a
Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, Noriko Noguchi   +10 more
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SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps

Experimental and Molecular Medicine
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent inflammation and epithelial cell dysfunction, but the underlying molecular mechanisms remain poorly understood. Here we show that dysregulated lipid metabolism and increased
Jaewoo Park, Jung Yeon Jang, Jeong Heon Kim, Se Eun Yi, Yeong Ju Lee, Myeong Sang Yu, Yoo-Sam Chung, Yong Ju Jang, Ji Heui Kim, Kyuho Kang   +9 more
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Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases

Frontiers in Pharmacology
Pulmonary diseases are a major category of diseases that pose a threat to human health. The most common drugs currently used to treat lung diseases are still chemical drugs, but this may lead to drug resistance and damage to healthy organs in the body ...
Yundou Liu, Chunyi Wang, Mengru Li, Yi Zhu, Ke Liu, Yufei Liu, Maocai Luo, Chuantao Zhang   +7 more
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Disruption of a Maize 9-Lipoxygenase Results in Increased Resistance to Fungal Pathogens and Reduced Levels of Contamination with Mycotoxin Fumonisin

Molecular Plant-Microbe Interactions, 2007
Plant oxylipins, produced via the lipoxygenase (LOX) pathway, function as signals in defense and development. In fungi, oxylipins are potent regulators of mycotoxin biosynthesis and sporogenesis.
Xiquan Gao, Won-Bo Shim, Cornelia Göbel, Susan Kunze, Ivo Feussner, Robert Meeley, Peter Balint-Kurti, Michael Kolomiets   +7 more
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Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis

Redox Experimental Medicine
Objective: Nonalcoholic steatohepatitis is a chronic liver disease caused by the progression of hepatocellular death and inflammation from simple steatosis. However, the pathogenesis of this disease remains unclear.
Kota Saito, Yuta Matsuoka, Masami Abe, Nao Kato, Kazushi Morimoto, Ken-ichi Yamada   +5 more
doaj   +1 more source