Journal of Lipid Research, 2023 Natural variations in the 13C:12C ratio (carbon-13 isotopic abundance [δ13C]) of the food supply have been used to determine the dietary origin and metabolism of fatty acids, especially in the n-3 PUFA biosynthesis pathway.
Daniel K. Chen +10 more
doaj +1 more source
Cell Death via Lipid Peroxidation and Protein Aggregation Diseases
Biology, 2021 Lipid peroxidation of cellular membranes is a complicated cellular event, and it is both the cause and result of various diseases, such as ischemia-reperfusion injury, neurodegenerative diseases, and atherosclerosis.
Katsuya Iuchi +2 more
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Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons
Neurobiology of Pain, 2020 Endogenous lipid mediators are proposed to contribute to headache and facial pain by activating trigeminal neurons (TN). We recently identified 11-hydroxy-epoxide- and 11-keto-epoxide derivatives of linoleic acid (LA) that are present in human skin and ...
Suzanne Doolen +2 more
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Cell Death Discovery, 2022 Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze +2 more
doaj +1 more source
Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis
Cells, 2023 Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine (an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted antioxidants SkQ1 and MitoTEMPO.
Konstantin G. Lyamzaev +4 more
doaj +1 more source
Studies on ferrous ion-induced lipid peroxidation of rat liver mitochondria. I. Effect of inorganic phosphate [PDF]
, 1974 Effect of inorganic phosphate on ferrous ion- and ascorbate-induced lipid. peroxidations of isolated rat liver mitochondria was investigated. As a result it has been shown that phosphate accelerates the ferrous ion.induced lipid peroxidation; namely ...
Yamamoto, Goki +4 more
core +1 more source
Elevated levels of erythrocyte-conjugated dienes indicate increased lipid peroxidation in schistosomiasis mansoni patients [PDF]
, 2004 Schistosoma mansoni causes liver disease by inducing granulomatous inflammation. This favors formation of reactive oxygen species, including superoxide ions, hydrogen peroxide and hydroxyl radicals all of which may induce lipid peroxidation.
Owen, JS +11 more
core +1 more source
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration
Neural Regeneration Research, 2023 Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders.
Irene Villalón-García +10 more
doaj +1 more source
The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]
, 2012 Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana +8 more
core +1 more source
Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage
Antioxidants, 2020 Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety.
Rafael Félix +5 more
doaj +1 more source