Results 41 to 50 of about 1,576,990 (299)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Machine Learning, Quantum Mechanics, and Chemical Compound Space

, 2016
We review recent studies dealing with the generation of machine learning models of molecular and solid properties. The models are trained and validated using standard quantum chemistry results obtained for organic molecules and materials selected from ...
Adamo, Arsenault, Balabin, Baldi, Bartók, Behler, Behler, Bereau, Bereau, Botu, Botu, Büttiker, Caccin, Curtiss, Dobson, Dral, Dral, Drwal, Faber, Faber, Faulon, Feynman, Fisher, Frisch, Furche, Ghasemi, Ghiringhelli, Golbraikh, Grimme, Hammett, Hammett, Hansen, Hansen, Hansen, Harvey, Hastie, Helgaker, Ho, Hoffmann, Hu, Huan, Hättig, Ivanciuc, Jensen, Karthikeyan, Kayala, Kirkpatrick, Kohn, Kubinyi, Landauer, Landauer, Li, Lipinski, Lopez-Bezanilla, Lorenz, Lusci, Manzhos, Manzhos, Meredig, Misra, Montavon, Montavon, Moussa, Müller, Nørskov, Parr, Perdew, Perdew, Pettifor, Pilania, Popelier, Prodan, Pyykko, Pyzer-Knapp, Ramakrishnan, Ramakrishnan, Ramakrishnan, Ramakrishnan, Ramakrishnan, Rappé, Rasmussen, Ruddigkeit, Rupp, Rupp, Rupp, Rupp, Sadowski, Schatz, Schneider, Schölkopf, Schütt, Snyder, Stevens, Stewart, Stewart, Sumpter, Tikhonov, Todeschini, Tuckerman, van Duin, von Lilienfeld, von Lilienfeld, Wagner, Weigend, Yanai, Zheng, Álvarez-Moreno   +106 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Bromine radical as a visible-light-mediated polarity-reversal catalyst

iScience, 2021
Summary: Polarity-reversal catalysts enable otherwise sluggish or completely ineffective reactions which are characterized by unfavorable polar effects between radicals and substrates. We herein disclose that when irradiated by visible light, bromine can
Han Wang, Haiwang Liu, Mu Wang, Meirong Huang, Xiangcheng Shi, Tonglin Wang, Xu Cong, Jianming Yan, Jie Wu   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Highly Reactive Cyclic Monoaryl Iodoniums Tuned as Carbene Generators Couple with Nucleophiles under Metal-Free Conditions

iScience, 2020
Summary: Cross-coupling reactions between aryl iodide and nucleophiles have been well developed. Iodoniums equipped with a reactive C-I(III) bond accelerate cross-coupling reactions of aryl iodide.
Haiwen Wang, Liyun Liang, Zhirong Guo, Hui Peng, Shuang Qiao, Nemai Saha, Daqian Zhu, Wenbin Zeng, Yunyun Chen, Peng Huang, Shijun Wen   +10 more
doaj   +1 more source

Direct allylic acylation via cross-coupling involving cooperative N‑heterocyclic carbene, hydrogen atom transfer, and photoredox catalysis

Nature Communications, 2023
Herein, we report a mild, operationally simple, multicatalytic method for the synthesis of β,γ-unsaturated ketones via allylic acylation of alkenes. Specifically, the method combines N‑heterocyclic carbene catalysis, hydrogen atom transfer catalysis, and
Xiaochen Wang, Rongxin Yang, Binbing Zhu, Yuxiu Liu, Hongjian Song, Jianyang Dong, Qingmin Wang   +6 more
doaj   +1 more source

Synthesis of poly-α/β-peptides with tunable sequence via the copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride

iScience, 2021
Summary: The fascinating functions of proteins and peptides in biological systems have attracted intense interest to explore their mimics using polymers, including polypeptides synthesized from polymerization.
Min Zhou, Jingcheng Zou, Longqiang Liu, Ximian Xiao, Shuai Deng, Yueming Wu, Jiayang Xie, Zihao Cong, Zhemin Ji, Runhui Liu   +9 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

iScience, 2022
Summary: One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal.
Xiaoming Ma, Wei Zhang
doaj   +1 more source