Results 41 to 50 of about 1,594,384 (300)

The cometary composition of a protoplanetary disk as revealed by complex cyanides

, 2015
Observations of comets and asteroids show that the Solar Nebula that spawned our planetary system was rich in water and organic molecules. Bombardment brought these organics to the young Earth's surface, seeding its early chemistry.
A Dutrey, A Dutrey, C Brinch, C Favre, C Qi, C Qi, C Qi, C Walsh, C Walsh, C Walsh, C Walsh, Chunhua Qi, D Lynden-Bell, D Semenov, David J. Wilner, DM Graninger, DP O’Brien, E Bergin, E Dartois, E Herbst, EC Fayolle, EF van Dishoeck, EF van Dishoeck, EI Chiang, FJ Ciesla, GM Muñoz Caro, H Nomura, JS Carr, K Furuya, K Tsiganis, KA Rosenfeld, Karin I. Öberg, Kenji Furuya, KI Öberg, KI Öberg, KI Öberg, KJ Walsh, KM Pontoppidan, L Hartmann, LI Cleeves, LI Cleeves, M Dubernet, M Simon, M Takami, M Wernli, MJ Mumma, MP Collings, MR Hogerheijde, N Goldman, N Sakai, P D'Alessio, P Gratier, P Hartogh, RT Garrod, Ryan Loomis, S Guilloteau, S Pizzarello, Sean M. Andrews, T Yamamoto, V Piétu, V Wakelam, Viviana V. Guzmán, Y Aikawa, Y Aikawa, Yuri Aikawa   +64 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

How do Structural Formulas Embody the Theory of Organic Chemistry? [PDF]

, 2008
Organic chemistry provides fertile ground for scholars interested in understanding the role of non-linguistic representations in scientific thinking. In this discipline, it is plausible to think of textual representation as supplementing theories whose ...
Goodwin, William
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interdisciplinary Research-Based Learning in Organic Chemistry and Microbiology Laboratories: Synthesis and Biological Testing of Novel Penicillin Derivatives [PDF]

, 2015
Interests in the mechanism that penicillin bestows on its target protein has driven the curiosity of its binding specificity towards the methicillin resistant strain of Staphylococcus areus, and its expression of a unique penicillin binding protein that ...
Rehberger, Kyle R.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Impact of cognitive abilities on performance in organic chemistry

Chemistry Teacher International, 2023
The purpose of this study was to observe the relationship between students’ cognitive abilities and their performance in organic chemistry. We were interested in measuring whether some cognitive composites were more predictive than others on organic ...
Nedungadi Sachin, Shenoy Sunaina
doaj   +1 more source

Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

iScience, 2022
Summary: One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of simple operation, high mass efficiency, low cost, and less amount of waste disposal.
Xiaoming Ma, Wei Zhang
doaj   +1 more source