Results 71 to 80 of about 1,581,698 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Increasing International Awareness in the Organic Chemistry Laboratory [PDF]

, 2019
Undergraduate ...
Fulmer, Sierrah
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

DNA Nucleobase Synthesis at Titan Atmosphere Analog by Soft X-rays

, 2009
Titan, the largest satellite of Saturn, has an atmosphere chiefly made up of N2 and CH4 and includes traces of many simple organic compounds. This atmosphere also partly consists of haze and aerosol particles which during the last 4.5 gigayears have been
Abbate M., Abe I., Basile B., Coll P., d’Hendecourt L. B., Gerakines P. A., Gibb E. L., Glaser R., Grasset O., Griffith C. A., Gueymard C. A., Imanaka H., Imanaka H., Kerkhof O., Khare B. N., Khare B. N., Khare B. N., Kobayashi K., Kobayashi K., Kobayashi K., Kobayashi K., Lappi S. E., Lorenz R. D., Lowe C. U., McDonald G. D., McGuigan M., Miller S. L., Mitri G., Moore M. H., Neish C. D., Nuevo M., Oró J., Oró J., Oró J., Pietrogrande M. C., Pilling S., Ponnamperuma C., Pullman B., Sagan C., Tran B. N., Tran B. N., Wakamatsu H., Wang F., Yamada Y., Yamanashi H., Yuasa S.   +45 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diastereoselective [Cu(MeCN)4BF4/BF3·Et2O]-Catalyzed Cyclopropenation of Alkynes: Asymmetric Synthesis of β-Amino-α-cyclopropenyl Phosphonates

SynOpen, 2017
The diastereospecific formation of β-amino-α-cyclopropenyl phosphonates has been achieved in moderate yields from the cyclopropenation of 1-alkynes with dialkyl α-diazophosphonates. The reaction was performed by using a combined catalyst consisting of Cu(
Haihong Ge, Shuang Liu, Yan Cai, Zenghui Gao, Siyi Du, Zhiwei Miao, Guixian Xie   +6 more
doaj   +1 more source

The properties of electrolyte solutions in nonaqueous and mixed solvents [PDF]

, 1986
This paper constitutes a reviev of the results of investigations on electrolyte solutions in some organic solvents that behaves similarly to water from thermochemical point of vi,»w as well as in some water - organic mixed solvents.
Piekarski, Henryk, Taniewska-Osińska, Stefania   +1 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Absorption capacity, kinetics and mechanical behaviour in dry and wet states of hydrophobic DEDMS/TEOS-based silica aerogels [PDF]

, 2017
This work is a new approach to the study of the structural, mechanical and absorption properties of hybrid organic/inorganic silica-based aerogels. Diethoxydimethylsilane and tetraethoxysilane have been used as precursors.
Braza, Verónica, Esquivias Fedriani, Luis María, Mesa Díaz, María del Mar, Morales Flórez, Víctor, Piñero de los Ríos, Manuel, Rosa Fox, Nicolás de la   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source