Results 181 to 190 of about 237,732 (257)

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Regioselective synthesis of aza-saccharins <i>via</i> anionic [1,4] Fries-type rearrangement of aryl sulfonimidoyl fluorides. [PDF]

Chem Sci
Leypold M, Poli L, Earl M, Putra OD, Kwapien K, Lewis RJ, Murphy JJ, Passamonti M, von Sydow LM, Spelling V, Asproudis I, Sardana M, Gatti C, Seki H, Lemaitre T, Juskaite R, Gopalakrishnan R, Francis SJ, Gardelli C, Norrby PO, Czechtizky W.   +20 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Correction: Hassan et al. <i>Brassica juncea</i> L. (Mustard) <i>Extract Silver</i> NanoParticles and Knocking off Oxidative Stress, ProInflammatory Cytokine and Reverse DNA Genotoxicity. <i>Biomolecules</i> 2020, <i>10</i>, 1650. [PDF]

Biomolecules
Hassan SA, Hagrassi AME, Hammam O, Soliman AM, Ezzeldin E, Aziz WM.   +5 more
europepmc   +1 more source

The Pharmaceutical Syllabus and Quantitative Pharmaceutical Chemistry

American Journal of Pharmaceutical Education, 1944
openaire   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

A sustainable spectrofluorimetric method for ivabradine quantification based on erythrosin B quenching with quantum mechanical modeling and Box-Behnken design optimization. [PDF]

RSC Adv
Alqahtani AS, Abduljabbar MH, Alnemari RM, Althobaiti MM, Aldawsari MF, Al-Mutairi AA, Serag A, Almalki AH.   +7 more
europepmc   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

RETRACTED: Cavalu et al. Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol Against Gram-Negative Bacterial Pathogens. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 13088. [PDF]

Int J Mol Sci
Cavalu S, Elbaramawi SS, Eissa AG, Radwan MF, Ibrahim TS, Khafagy ES, Lopes BS, Ali MAM, Hegazy WAH, Elfaky MA.   +9 more
europepmc   +1 more source

Qualitative Chemistry and Qualitative Pharmaceutical Chemistry

American Journal of Pharmaceutical Education, 1944
openaire   +1 more source