Results 1 to 10 of about 1,084,156 (359)

Alteration in plasma and striatal levels of d-serine after d-serine administration with or without nicergoline: An in vivo microdialysis study

Heliyon, 2017
Aims: d-Serine (d-Ser), a co-agonist of N-methyl-d-aspartate receptor (NMDAR), is effective for treating schizophrenia. The present study investigated changes in plasma and striatal d-Ser levels in Sprague-Dawley (SD) rats after intraperitoneal d-Ser ...
Mayu Onozato, Hiromi Nakazawa, Katsuyuki Ishimaru, Chihiro Nagashima, Minori Fukumoto, Hitomi Hakariya, Tatsuya Sakamoto, Hideaki Ichiba, Takeshi Fukushima   +8 more
doaj   +1 more source

India and the Patent Wars: Pharmaceuticals in the New Intellectual Property Regime [PDF]

, 2017
[Excerpt] India and the Patent Wars contributes to an international debate over the costs of medicine and restrictions on access under stringent patent laws showing how activists and drug companies in low-income countries seize agency and exert ...
Halliburton, Murphy
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Green and Sustainable Approaches in Pharmaceutical Sciences [PDF]

, 2023
Shiv Bahadur, Radhika Radhika, DurgeshNandini Chauhan, NagendraSingh Chauhan, Kamal Shah   +4 more
openalex   +1 more source

Implementing R&D policies : an analsysis of Spain´s pharmaceutical research program [PDF]

, 2004
We analyze Spain’s National Pharmaceutical Research Program using detailed firm-l vel data. We fin differences between ex ante announced evaluation criteria and ex post implementation.
Desmet, Klaus, Kujal, Praveen, Lobo, Félix   +2 more
core   +5 more sources

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Heliyon, 2018
Androgen biosynthesis in males occurs to a large extent in testicular Leydig cells. This study focused on the evaluation of three murine Leydig cell lines as potential screening tool to test xenobiotics interfering with gonadal androgen synthesis.
Roger T. Engeli, Cornelia Fürstenberger, Denise V. Kratschmar, Alex Odermatt   +3 more
doaj   +1 more source

A Comparison of U. S. and European University-Industry Relations in the Life Sciences [PDF]

, 2002
We draw on diverse data sets to compare the institutional organization of upstream life science research across the United States and Europe. Understanding cross-national differences in the organization of innovative labor in the life sciences requires ...
Arora A., Batagelj V., Ben-David J., Fabio Pammolli, Geiger R., Greenacre M. J., Greenacre M. J., Guyon X., Guyon X., Jason Owen-Smith, Massimo Riccaboni, Morange M., Mowery D., Orsenigo L., Owen-Smith J., Pammolli F., Pavitt K., Peterson J., Stokes D. E., Walter W. Powell, Winkler G., Zucker L. G.   +21 more
core   +3 more sources

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

Heliyon, 2019
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a clinical need to develop more effective drugs with fewer adverse reactions.Chalcones are one of the ...
Josefina Higgs, Cristina Wasowski, Alejandra Marcos, Marko Jukič, Carlos Humberto Paván, Stanislav Gobec, Felicitas de Tezanos Pinto, Natalia Colettis, Mariel Marder   +8 more
doaj   +1 more source

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery

iScience, 2020
Summary: Two opposing viewpoints are held regarding the need for understanding a drug's molecular target and mechanism of action. One extreme viewpoint is that it is unnecessary, because, after all, there are many beneficial drugs in use for which the ...
Ronald L. Davis
doaj   +1 more source

DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling

iScience, 2021
Summary: The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks.
Ali Kishk, Maria Pires Pacheco, Thomas Sauter   +2 more
doaj   +1 more source

Recent advances in pharmaceutical sciences VII [PDF]

, 2017
The E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences.
Feliu José, Carlos, Muñoz-Torrero López-Ibarra, Diego, Riu Aumatell, Montserrat   +2 more
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