Results 1 to 10 of about 519,309 (312)

Dinutuximab beta effectively treats Ewing sarcoma when combined with chemotherapy

iScience
Summary: Ewing sarcoma is a rare and aggressive cancer of the bone and soft tissues primarily affecting children and young adults. Prognosis for patients with metastatic or recurrent disease remains poor despite intensive multimodal therapy, highlighting
Roberta Frapolli, Marina Meroni, Ezia Bello, Lorenza Pirona, Elisa Callegari, Valentina Kebede, Isabella Pellerani, Simone Canesi, Eugenio Scanziani, Uta Dirksen, Patrizia Angelico, Stefano Biondi, Matteo Malinverno   +12 more
doaj   +1 more source

Antibacterial activities of green tea crude extracts and synergistic effects of epigallocatechingallate (EGCG) with gentamicin against MDR pathogens

Heliyon, 2019
Plant extracts and their purified compounds were examined for synergistic antimicrobial activity using selected multi-drug resistant (MDR) pathogens.
Md. Anowar Khasru Parvez, Karabi Saha, Juairia Rahman, Rahath Ara Munmun, Md. Atikur Rahman, Shuvra Kanti Dey, Md. Shahedur Rahman, Sohidul Islam, Mohammad Hossain Shariare   +8 more
doaj   +1 more source

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

Heliyon, 2019
Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a clinical need to develop more effective drugs with fewer adverse reactions.Chalcones are one of the ...
Josefina Higgs, Cristina Wasowski, Alejandra Marcos, Marko Jukič, Carlos Humberto Paván, Stanislav Gobec, Felicitas de Tezanos Pinto, Natalia Colettis, Mariel Marder   +8 more
doaj   +1 more source

Alteration in plasma and striatal levels of d-serine after d-serine administration with or without nicergoline: An in vivo microdialysis study

Heliyon, 2017
Aims: d-Serine (d-Ser), a co-agonist of N-methyl-d-aspartate receptor (NMDAR), is effective for treating schizophrenia. The present study investigated changes in plasma and striatal d-Ser levels in Sprague-Dawley (SD) rats after intraperitoneal d-Ser ...
Mayu Onozato, Hiromi Nakazawa, Katsuyuki Ishimaru, Chihiro Nagashima, Minori Fukumoto, Hitomi Hakariya, Tatsuya Sakamoto, Hideaki Ichiba, Takeshi Fukushima   +8 more
doaj   +1 more source

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Heliyon, 2018
Androgen biosynthesis in males occurs to a large extent in testicular Leydig cells. This study focused on the evaluation of three murine Leydig cell lines as potential screening tool to test xenobiotics interfering with gonadal androgen synthesis.
Roger T. Engeli, Cornelia Fürstenberger, Denise V. Kratschmar, Alex Odermatt   +3 more
doaj   +1 more source

Mechanism of Action and Target Identification: A Matter of Timing in Drug Discovery

iScience, 2020
Summary: Two opposing viewpoints are held regarding the need for understanding a drug's molecular target and mechanism of action. One extreme viewpoint is that it is unnecessary, because, after all, there are many beneficial drugs in use for which the ...
Ronald L. Davis
doaj   +1 more source

DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling

iScience, 2021
Summary: The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks.
Ali Kishk, Maria Pires Pacheco, Thomas Sauter   +2 more
doaj   +1 more source

Celebrating Women in the Pharmaceutical Sciences [PDF]

Molecular Pharmaceutics, 2021
Lynne S. Taylor, Christel A. S. Bergström, Afsaneh Lavasanifar, Feng Qian, Raj Suryanarayanan, Kristofer J. Thurecht   +5 more
openaire   +4 more sources

Antitumour, acute toxicity and molecular modeling studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one against Ehrlich ascites carcinoma and sarcoma-180

Heliyon, 2018
In an effort to discover an effective and selective antitumour agent, synthesis and anti-cancer potential of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one (SK-25), which has been reported earlier by us with significant cytotoxicity towards ...
Dinesh Kumar, Pooja Sharma, Kunal Nepali, Girish Mahajan, Mubashir J. Mintoo, Amarinder Singh, Gurpreet Singh, Dilip M. Mondhe, Gurdarshan Singh, Subheet K. Jain, Girish K. Gupta, Fidele Ntie-Kang   +11 more
doaj   +1 more source

A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs

Heliyon, 2018
Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine.
Fatemeh Farjadian, Soha Azadi, Soliman Mohammadi-Samani, Hajar Ashrafi, Amir Azadi   +4 more
doaj   +1 more source