Results 1 to 10 of about 10,859,059 (267)

Genetic Biosensor Design for Natural Product Biosynthesis in Microorganisms

Trends in Biotechnology, 2020
Low yield and low titer of natural products are common issues in natural product biosynthesis through microbial cell factories. One effective way to resolve such bottlenecks is to design genetic biosensors to monitor and regulate the biosynthesis of ...
Gazi Sakir Hossain, Mukesh Saini, Ryoma Miyake   +2 more
exaly   +2 more sources

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Antioxidants, 2022
The rapid spread of antibiotic resistance and lack of effective drugs for treating infections caused by multi-drug resistant bacteria in animal and human medicine have forced us to find new antibacterial strategies.
Chongshan Dai, Jiahao Lin, Hui Li, Zhangqi Shen, Yang Wang, T. Velkov, Jianzhong Shen   +6 more
semanticscholar   +1 more source

Chemical Evolution of Natural Product Structure

Journal of the American Chemical Society, 2022
Natural products are the result of Nature’s exploration of biologically relevant chemical space through evolution and an invaluable source of bioactive small molecules for chemical biology and medicinal chemistry.
Michael Grigalunas, S. Brakmann, H. Waldmann   +2 more
semanticscholar   +1 more source

Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

Antioxidants, 2022
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed
InWha Park, Goeun Park, Yoojin Choi, Seung-Woo Jo, Hak Cheol Kwon, Jin-Soo Park, Jin Wook Cha   +6 more
doaj   +1 more source

SuperNatural 3.0—a database of natural products and natural product-based derivatives

Nucleic Acids Res., 2022
Natural products (NPs) are single chemical compounds, substances or mixtures produced by a living organism - found in nature. Evolutionarily, NPs have been used as healing agents since thousands of years and still today continue to be the most important ...
Kathleen Gallo, Emanuel Kemmler, A. Goede, Finnja Becker, Mathias Dunkel, R. Preissner, Priyanka Banerjee   +6 more
semanticscholar   +1 more source

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Microbiology Spectrum, 2022
Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target.
Sandra Hoefgen, Alexander U. Bissell, Ying Huang, Fabio Gherlone, Luka Raguž, Christine Beemelmanns, Vito Valiante   +6 more
doaj   +1 more source

Minerals Composition and Characterization of the Hatchery Eggshell Waste Treated with Different Preparation Methods

Jurnal Ilmu dan Teknologi Hasil Ternak, 2021
The preparation process needs to be carried out in the treatment of hatchery waste. The objective of the study was to determine the mineral content and characterization of the eggshell waste after preparation.
Ahmad Iskandar Setiyawan, Diah Pratiwi, Mohammad Faiz Karimy, Safna Fauziah   +3 more
doaj   +1 more source

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Angewandte Chemie, 2021
Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments.
George Karageorgis, Daniel J. Foley, Luca Laraia, S. Brakmann, H. Waldmann   +4 more
semanticscholar   +1 more source

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

Virulence, 2022
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C.
Stefanie Allert, Daniela Schulz, Philipp Kämmer, Peter Großmann, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Sascha Brunke, Bernhard Hube   +8 more
doaj   +1 more source

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source