Results 1 to 10 of about 4,560,586 (338)

Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

open access: yesAntioxidants, 2022
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed
InWha Park   +6 more
doaj   +1 more source

Marine Natural Products [PDF]

open access: yesChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Blunt, J.W.   +4 more
openaire   +10 more sources

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

open access: yesMicrobiology Spectrum, 2022
Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target.
Sandra Hoefgen   +6 more
doaj   +1 more source

Scalemic natural products

open access: yesNatural Product Reports, 2023
In natural products, a low optical purity is not generally associated with a sloppy enzymatic activity, but rather with the co-expression of antipodal enzymes/directing proteins or, alternatively, with erosion by enzymatic or spontaneous reactions.
Mazzotta, Sarah   +5 more
openaire   +2 more sources

Pseudo Natural Products—Chemical Evolution of Natural Product Structure [PDF]

open access: yesAngewandte Chemie International Edition, 2021
AbstractPseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments. They inherit key biological characteristics of the guiding natural product, such as chemical and physiological properties, yet ...
George Karageorgis   +4 more
openaire   +6 more sources

Minerals Composition and Characterization of the Hatchery Eggshell Waste Treated with Different Preparation Methods

open access: yesJurnal Ilmu dan Teknologi Hasil Ternak, 2021
The preparation process needs to be carried out in the treatment of hatchery waste. The objective of the study was to determine the mineral content and characterization of the eggshell waste after preparation.
Ahmad Iskandar Setiyawan   +3 more
doaj   +1 more source

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

open access: yesVirulence, 2022
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C.
Stefanie Allert   +8 more
doaj   +1 more source

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

open access: yesMolecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai   +4 more
doaj   +1 more source

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

open access: yesBMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai   +3 more
doaj   +1 more source

Natural products genomics [PDF]

open access: yesMicrobial Biotechnology, 2008
Secondary metabolites (or natural products) are often synthesized by multi‐modular, multi‐domain proteins called non‐ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS). Various well‐known metabolites produced by microorganisms are listed in Table 1, and examples of structures are shown in Fig. 1. In particular, Streptomyces species are
Siezen, R.J., Khayatt, B.
openaire   +4 more sources

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