Results 1 to 10 of about 8,201,019 (210)

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods [PDF]

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +6 more sources

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening [PDF]

BMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai, Young-Joon Ko, Cheol-Ho Pan, Keunwan Park   +3 more
doaj   +4 more sources

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors

Journal of Cheminformatics, 2023
Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds.
Prasannavenkatesh Durai, Sue Jung Lee, Jae Wook Lee, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +2 more sources

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

Frontiers in Chemistry, 2021
Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million new cases each year, for which the available therapies have serious limitations.
Crhisllane Rafaele dos Santos Vasconcelos, Crhisllane Rafaele dos Santos Vasconcelos, Antonio Mauro Rezende, Antonio Mauro Rezende   +3 more
doaj   +1 more source

Interaction studies of the human and Arabidopsis thaliana Med25-ACID proteins with the herpes simplex virus VP16- and plant-specific Dreb2a transcription factors. [PDF]

PLoS ONE, 2014
Mediator is an evolutionary conserved multi-protein complex present in all eukaryotes. It functions as a transcriptional co-regulator by conveying signals from activators and repressors to the RNA polymerase II transcription machinery.
Ximena Aguilar, Jeanette Blomberg, Kristoffer Brännström, Anders Olofsson, Jürgen Schleucher, Stefan Björklund   +5 more
doaj   +1 more source

Characterization of polyvalent Escherichia phage Sa157lw for the biocontrol potential of Salmonella Typhimurium and Escherichia coli O157:H7 on contaminated mung bean seeds

Frontiers in Microbiology, 2022
Seeds are one of the primary sources of contamination with foodborne pathogens, such as pathogenic Escherichia coli, and various Salmonella serovars, for produce, particularly sprouts.
Yen-Te Liao, Yujie Zhang, Alexandra Salvador, Kan-Ju Ho, Michael B. Cooley, Vivian C. H. Wu   +5 more
doaj   +1 more source

Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background The effects of some drugs, aging, cancers, and other diseases can cause muscle wasting. Currently, there are no effective drugs for treating muscle wasting.
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Keunwan Park, Chan Hee Lee, Kae Won Cho, Yun Kyung Lee, Jae‐Young Lim, Jeong Kyo Yoon, Sae Hwan Lee, Hyog Young Kwon   +10 more
doaj   +1 more source

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1

Biomolecules, 2019
Ubiquitin binding domains (UBDs) are modular elements that bind non-covalently to ubiquitin and act as downstream effectors and amplifiers of the ubiquitination signal. With few exceptions, UBDs recognize the hydrophobic path centered on Ile44, including
Ridvan Nepravishta, Federica Ferrentino, Walter Mandaliti, Anna Mattioni, Janine Weber, Simona Polo, Luisa Castagnoli, Gianni Cesareni, Maurizio Paci, Elena Santonico   +9 more
doaj   +1 more source

Evaluating cutinase from Fusarium oxysporum as a biocatalyst for the degradation of nine synthetic polymer

Scientific Reports
Plastic poses a significant environmental impact due to its chemical resilience, leading to prolonged and degradation times and resulting in widespread adverse effects on global flora and fauna.
Maycon Vinicius Damasceno de Oliveira, Gabriel Calandrini, Clauber Henrique Souza da Costa, Carlos Gabriel da Silva de Souza, Cláudio Nahum Alves, José Rogério A. Silva, Anderson H. Lima, Jerônimo Lameira   +7 more
doaj   +1 more source

Aryl-alcohol oxidases: catalysis, diversity, structure–function and emerging biotechnological applications

Applied Microbiology and Biotechnology
Aryl-alcohol oxidases (AAOs) are flavin-dependent enzymes of the glucose-methanol-choline (GMC) oxidoreductase superfamily that catalyze the oxidation of a broad range of activated primary alcohols into their corresponding aldehydes, generating hydrogen ...
Paula Cinca‑Fernando, Aurora Vázquez-Rodríguez, Juan Mangas‑Sánchez, Patricia Ferreira   +3 more
doaj   +1 more source